赣南医科大学学报2024，Vol.44Issue(11)：1121-1125,5.DOI:10.3969/j.issn.1001-5779.2024.11.005
CuI介导亚胺与2-碘代乙酸乙酯的Reformatsky反应合成β-氨基酯
CuI mediated synthesis of β-amino esters visa the Reformatsky reaction of imines with 2-iodoacetates
摘要
Abstract
Objective:To develop a simple and efficient cuprous iodide-mediated catalytic system of Reformatsky reaction.Methods:The Reformatsky reaction of ethyl iodoacetate 2a with imines 1 was efficiently catalyzed by zinc powder and mediated by the cheap and easily available cuprous iodide with acetonitrile/water mixed solvent as the reaction solvent.Results:The Reformatsky addition products β-amino esters 3 can be obtained with high yield(up to 95%)under mild conditions and the structures of products 3 were characterized by 1H NMR、13C NMR and HRMS.In addition,according to the previous research and the related literature,the possible reaction mechanism was proposed.Conclusion:Mediated by cuprous iodide,the Reformatsky reaction of ethyl iodoacetate 2a with imines 1 can be scaled up to the gram scale,which is conducive to industrial production.关键词
铜/锌/Reformatsky反应/β-氨基酯/2-碘代乙酸乙酯Key words
Cuprum/Zinc/Reformatsky reaction/β-amino esters/2-iodoacetates分类
化学化工引用本文复制引用
钟瑜红,税红灵,张占义,刘子仪,王新颖,徐言妍,罗年华..CuI介导亚胺与2-碘代乙酸乙酯的Reformatsky反应合成β-氨基酯[J].赣南医科大学学报,2024,44(11):1121-1125,5.基金项目
江西省教育厅科学技术研究项目(GJJ211541,GJJ180801) （GJJ211541,GJJ180801）
江西省科技厅青年项目(20161BAB213059) （20161BAB213059）
赣南医学院校启动金项目(QD201816) （QD201816）
江西省大学生创新创业训练计划项目(S202210413034) （S202210413034）
