赣南医科大学学报2024，Vol.44Issue(11)：1126-1131,6.DOI:10.3969/j.issn.1001-5779.2024.11.006
抗溃疡剂佐利米定及其含氟衍生物的合成研究
Study on the synthesis of antiulcer agent Zolimidine and its fluorinated derivatives
摘要
Abstract
Objective:To explore the synthesis of the antiulcer agent Zolimidine and its fluorinated derivative.Methods:Zolimidine was synthesized from 2-aminopyridine and 2-bromo-1-(4-methanesulfonyl)acetophenone,and then reacted with trifluoroacetaldehyde hydrate,trifluoromethylacetone esters,and difluoroacetaldehyde ethyl hemiacetal to synthesize corresponding fluorinated derivatives.Results:Zolimidine and its fluorinated derivatives were synthesized.The chemical structures of the target compounds were confirmed by 1H NMR,13C NMR,19F NMR and HR-MS.Conclusion:The synthesis methods of Zolimidine and its fluorinated derivatives has the advantages of simple process,high yield,and convenient operation.关键词
佐利米定/有机合成/含氟化合物Key words
Zolimidine/Organic synthesis/Fluorine compounds分类
医药卫生引用本文复制引用
朱雪,付鑫磊,余树琴,陈才博,李镇霖,郭小华,杨凯..抗溃疡剂佐利米定及其含氟衍生物的合成研究[J].赣南医科大学学报,2024,44(11):1126-1131,6.基金项目
江西省高等学校大学生创新创业训练计划项目(S202310413008) （S202310413008）
江西省科技厅自然科学基金面上项目(20224BAB203010) （20224BAB203010）
