赣南医科大学学报2024，Vol.44Issue(11)：1156-1162,7.DOI:10.3969/j.issn.1001-5779.2024.11.012
电针调控小胶质细胞极化干预神经病理性痛的研究进展
The role of electroacupuncture in modulating microglial polarization for treatment of neuropathic pain
摘要
Abstract
Neuropathic pain is a chronic condition resulting from nervous system damage or dysfunction,characterized by complex pathophysiology and significant challenges for clinical treatment.Microglia plays a crucial role in the initiation and progression of neuropathic pain through their activation and regulation within the central nervous system.Activated microglia promote the release of inflammatory mediators,contributing to the formation and maintenance of central sensitization.Electroacupuncture(EA),a traditional and effective non-pharmacological therapy,alleviates neuropathic pain by modulating microglial polarization,reducing the production of pro-inflammatory factors,and enhancing the release of anti-inflammatory factors,thereby inhibiting central sensitization.This review summarizes the role of microglia in neuropathic pain and explores how EA modulates microglial activity to mitigate this pain,aiming to provide a theoretical basis for clinical treatment.关键词
神经病理性痛/电针/小胶质细胞极化Key words
Neuropathic pain/Electroacupuncture/Microglial polarization分类
医药卫生引用本文复制引用
陈宣军,单热爱,黄诚..电针调控小胶质细胞极化干预神经病理性痛的研究进展[J].赣南医科大学学报,2024,44(11):1156-1162,7.基金项目
国家自然科学基金项目(82260233) （82260233）
