赣南医科大学学报2024，Vol.44Issue(11)：1176-1180,5.DOI:10.3969/j.issn.1001-5779.2024.11.015
全身麻醉中肌肉松弛拮抗剂应用的研究进展
Progress in the application of muscle relaxant antagonists during general anesthesia
韩乐 1张雨 1邱嘉欣 1谢海玉2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一临床医学院||赣南医科大学第一附属医院麻醉手术中心,江西 赣州 341000
- 折叠
摘要
Abstract
Muscle relaxation is an essential condition in general anesthesia and surgery for tracheal intubation.However,residual muscle relaxants induced by muscle relaxants after surgery is a common complication that may have adverse effects on patients.In order to reduce the occurrence of this situation,muscle relaxant antagonists are usually used in clinical practice,including cholinesterase inhibitors,amino steroid antagonists and new muscle relaxant antagonists.This article reviews the pharmacological mechanism and the latest clinical application of muscle relaxant antagonists during general anesthesia for tracheal intubation.The results of literature review showed that the use of neostigmine should pay attention to the timing of administration and choose the appropriate dose.Reversal of deep block with neostigmine is not recommended in the absence of any sign of neuromuscular recovery.Sugammadex can reverse intermediate and deep neuromuscular blockade faster and more completely.Sugammadex has good efficacy and safety in thoracic surgery with one lung ventilation.Adamgammadex is a novel γ-cyclodextamine derivative,which has fewer adverse reactions against steroidal muscle relaxants than sugammadex.L-cysteine can quickly reverse gantacurium and CW002 induced neuromuscular blockade.Calabadion can be combined with steroids and benzisoquinoline muscle relaxants at the same time to quickly reverse muscle relaxants.However,the clinical application of new muscle relaxant antagonists needs further research.In clinical practice,anesthesiologists should use antagonists rationally and individually according to clinical needs.关键词
麻醉,全身/舒更葡糖钠/新斯的明/肌张力过低/拮抗剂/神经肌肉阻滞Key words
Anesthesia,general/Sugammadex/Neostigmine/Low muscle tone/Antagonist/Neuromuscular block分类
医药卫生引用本文复制引用
韩乐,张雨,邱嘉欣,谢海玉..全身麻醉中肌肉松弛拮抗剂应用的研究进展[J].赣南医科大学学报,2024,44(11):1176-1180,5.
