赣南医科大学学报2024，Vol.44Issue(11)：1181-1187,7.DOI:10.3969/j.issn.1001-5779.2024.11.016
组蛋白乳酸化修饰的研究进展
The research progress of histone lactylation
傅梦蝶 1廖伟2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学,江西 赣州 341000
- 折叠
摘要
Abstract
Lactic acid is the main metabolite of cellular glycolysis.It plays an important role in energy supply and signal transduction.As a reaction substrate,lactic acid can participate in the development of a variety of diseases.In 2019,it was first reported that histone lactylation could occur,and in recent years,histone lactylation was successively reported as a potential mechanism of disease occurrence.Studies have shown that histone lactate can change the tumor microenvironment to promote tumorigenesis,participate in the development of sepsis,promote brain aging and Alzheimer's disease through the NF-κB signaling pathway,and participate in the development of other diseases.Although a large number of studies have shown that histone lactate can accelerate the development of the disease,it has also been reported that histone lactate plays a role in promoting the recovery of the disease.This article briefly introduces the role and potential mechanism of histone lactate modification in the development of clinical diseases,and provides a theoretical basis for the study of histone post-translational modification.关键词
组蛋白/乳酸化修饰/翻译后修饰/肿瘤Key words
Histone/Lactylation/Post-translational modification/Tumor分类
生物科学引用本文复制引用
傅梦蝶,廖伟..组蛋白乳酸化修饰的研究进展[J].赣南医科大学学报,2024,44(11):1181-1187,7.
