广州医药2024，Vol.55Issue(11)：1237-1245,9.DOI:10.20223/j.cnki.1000-8535.2024.11.001
乳酸化修饰在肿瘤中的研究进展
The role of lactation modification in tumors
摘要
Abstract
Lactic acid was previously regarded as a metabolic waste product with no biological function.As lactic acid has been intensively studied,it has been found to have multiple roles.Lactation modification is a recently discovered protein post-translational modification process related to lactic acid.There are two main types of lactation modification:one is direct modification related to lactic acid and the other is indirect modification related to pyruvate.Both types of lactation modification may be regulated by various aspects such as glycolysis,lactate transport and accumulation,protein crosstalk,and the nervous system.Lactation modification can play an important role in metabolic reprogramming,proliferation,migration,and immune escape of tumor tissues by directly or indirectly modifying histones or non-histone proteins.The in-depth study of lactation modification is expected to find new pathways for tumor diagnosis and treatment.Therefore,in order to clarify the research progress of lactation modification in tumors,this paper presents a review on the molecular mechanism of protein lactation modification and the research progress of its role in tumors.关键词
乳酸化修饰/增殖/迁移/免疫逃逸/肿瘤Key words
lactation modification/proliferation/migration/immune escape/tumor引用本文复制引用
洪雅滢,郑莉,谢涛,赵善超..乳酸化修饰在肿瘤中的研究进展[J].广州医药,2024,55(11):1237-1245,9.基金项目
2019年国家自然科学基金(K10120033) （K10120033）
