广州医药2024，Vol.55Issue(11)：1246-1254,9.DOI:10.20223/j.cnki.1000-8535.2024.11.002
肠道菌群-PPARs轴在炎症性肠病中的作用
The role of PPARs-gut microbiota axis in inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD),characterized as a chronic and recurrent inflammatory condition,is classified by the World Health Organization as one of the intractable diseases in modern medicine.The precise pathogenesis of IBD remains unclear,but current research widely believes that it is closely related to dysbiosis of the gut microbiota.Imbalance in the gut flora triggers an excessive immune response in the host’s intestinal mucosa,leading to mucosal damage in genetically susceptible individuals.To date,no specific targets have been identified that can cure IBD.Peroxisome proliferator-activated receptors(PPARs),as members of the nuclear receptor superfamily,play significant roles in growth and development,inflammation regulation,and metabolic processes.They are regarded as potential effective targets for treating various diseases,including IBD,and are closely related to the gut microbiota.This review aims to discuss the progress in understanding the role of the relationship between PPARs and gut microbiota in IBD,so as to find new potential targets for the diagnosis and treatment of IBD,develop new treatment strategies,provide new ideas and methods for the diagnosis and treatment of IBD in clinical practice.关键词
肠道菌群/炎症性肠病/PPARsKey words
gut microbiota/inflammatory bowel disease/PPARs引用本文复制引用
李建洪,徐婧,徐豪明,黄琛,聂玉强,周有连..肠道菌群-PPARs轴在炎症性肠病中的作用[J].广州医药,2024,55(11):1246-1254,9.基金项目
国家自然科学基金(82370552) （82370552）
广东省自然科学基金(2023A1515030214) （2023A1515030214）
广州市青年科技托举人才(QT-2023-033) （QT-2023-033）
