广州医药2024，Vol.55Issue(11)：1255-1263,1268,10.DOI:10.20223/j.cnki.1000-8535.2024.11.003
基于Hedgehog信号通路的中医药干预慢性萎缩性胃炎的研究进展
Research about Chinese medicine intervention in chronic atrophic gastritis based on the Hedgehog signaling pathway
摘要
Abstract
Chronic atrophic gastritis,a common precancerous lesion of gastric cancer,requires a long-term treatment and is difficult to cure.Therefore,it usually leads to decreased patient compliance.It will not only have a serious adverse impact on the patient’s physical and mental health and quality of life,but also cause a burden to the patient’s family,which has become a difficult problem that can not be ignored clinically.However,the pathogenesis has not yet been totally clarified,not to mention a consensus on the clinical treatment.This paper reviews the research revolving around Chinese medicine intervention in chronic atrophic gastritis based on the Hedgehog signaling pathway in the last decade.It’s creative therapy of chronic atrophic gastritis that utilizing Traditional Chinese Medicine to regulate and control Hedgehog signaling pathway,which has been increasingly reported in recent years.This paper is based on"deficiency in origin"and"excess in superficiality"principle.Concretely,spleen-stomach vacuity is characterized by deficiency in origin,and excess in superficiality manifests blood stasis,qi stagnation,dampness-heat and phlegm turbidity as excess in superficiality.By this way,the paper explores the effect of prescription selection on chronic atrophic gastritis.It is believed that the modern therapy that combines traditional Chinese medicine with Hedgehog signaling pathway can tackle chronic atrophic gastritis,thus providing a reference for further clinical trials and practices.关键词
Hedgehog信号通路/中医药/慢性萎缩性胃炎/研究进展/综述Key words
Hedgehog signal pathway/Chinese medicine/chronic atrophic gastritis/research progress/review引用本文复制引用
李海萍,谢佳怡,黎晓晴,邵炜竣,张伦,邱健行..基于Hedgehog信号通路的中医药干预慢性萎缩性胃炎的研究进展[J].广州医药,2024,55(11):1255-1263,1268,10.基金项目
广州市科学技术局第十二批基础与应用基础研究计划项目(202201011782) （202201011782）
