广州医药2024，Vol.55Issue(11)：1297-1302,6.DOI:10.20223/j.cnki.1000-8535.2024.11.009
25-羟维生素D水平与糖尿病周围神经病变发生的相关性研究
Correlation study between 25-hydroxyvitamin D level and diabetic peripheral neuropathy
摘要
Abstract
Objective To explore the correlation of 25-hydroxyvitamin D[25-(OH)D]level in predicting the occurrence of diabetic peripheral neuropathy.Methods A total of 200 patients with type 2 diabetes mellitus(T2DM)who were admitted to Community Health Service Center of West Nanjing Road,Jing’an District,Shanghai from June 2021 and December 2021 were selected as the study subjects.According to physical examination,blood biochemistry,neurological symptom score and electromyography,the patients were divided into two groups:no peripheral neuropathy group(n=153)and peripheral neuropathy group(n=47).The general data and serum baseline 25-(OH)D levels of the two groups were compared to analyze the correlation between 25-(OH)D and diabetic peripheral neuropathy.The predictive value of 25-(OH)D in diabetic peripheral neuropathy was analyzed by Logistic regression.Results There were significant differences in baseline 25-(OH)D level,fasting blood glucose(FBG),HbA1c and SBP between two groups(P＜0.001),but no significant differences in age,sex,BMI,waist circumference,postprandial plasma glucose,AST,C-peptid total cholesterol,HDL-C,triglyceride,LDL-C,Scr,UA and DBP between two groups(P＞0.05).Baseline 25-(OH)D level was negatively correlated with MDNS score(r=-0.583,P＜0.001),and FBG was positively correlated with MDNS score(r=0.303,P＜0.001).Logistic regression analysis showed that the DPN risk decreased by 25%for every unit increase of 25-(OH)D,and the correlation remained after timely adjustment for sex,age,HbA1c,and LDL-C.Conclusions The level of 25-(OH)D is negatively correlated with the occurrence and development of diabetic peripheral neuropathy,and the detection of serum 25-(OH)D level can be used as an important indicator to predict the occurrence and development of urinary peripheral neuropathy.关键词
25-羟维生素D/糖尿病/周围神经病变Key words
25-hydroxyvitamin D/diabetes mellitus/peripheral neuropathy引用本文复制引用
庄丽,孙婉婉,徐彩勤,沈莹,许婷婷..25-羟维生素D水平与糖尿病周围神经病变发生的相关性研究[J].广州医药,2024,55(11):1297-1302,6.基金项目
上海市静安区卫生健康委员会社区专项课题(2021SQ01) （2021SQ01）
