广州医药2024，Vol.55Issue(11)：1308-1313,6.DOI:10.20223/j.cnki.1000-8535.2024.11.011
应变超声心动图早期检测蒽环类药物诱导的急性淋巴细胞白血病患儿左心室功能障碍
Strain echocardiography detecting left ventricular dysfunction in children with acute lymphocytic leukemia induced by anthracycloids
谢艳林 1董燕 1李翠玲 1董盖英1
作者信息
- 1. 广州市第一人民医院(华南理工大学附属第二医院）超声医学科(广东 广州 510180）
- 折叠
摘要
Abstract
Objective To evaluate cardiotoxicity in children with acute lymphoblastic leukemia treated with anthracyclines by echocardiography combined with 2D speckle tracking imaging,and to detect left heart dysfunction early.Methods In this prospective nonrandomized study,20 children with newly diagnosed acute lymphoblastic leukemia were assessed for cardiotoxicity by echocardiography and 2D speckle tracking imaging in three periods during the treatment.Results The left ventricular outflow tract velocity integral TVI and E,E/E’decreased during treatment,and went back to the pre-treatment value one year after diagnosis.In the longitudinal strain of 2D speckle tracking imaging,in GLPS-LAX,GLPS-A2C,LV-GLPS,there were statistical differences between treatment completed and after diagnosis,and between 1 year after diagnosis and treatment completed.However,GLPS-A4C has no statistical significance.Conclusions The conventional echocardiography combined with longitudinal overall strain of 2D speckle tracking imaging can comprehensively evaluate the early changes of left ventricular dysfunction caused by chemotherapy in children with leukemia.关键词
斑点追踪技术/白血病/蒽环类药物/心脏毒性Key words
speckle tracking imaging/leukemia/anthracycline drugs/cardiac toxicity引用本文复制引用
谢艳林,董燕,李翠玲,董盖英..应变超声心动图早期检测蒽环类药物诱导的急性淋巴细胞白血病患儿左心室功能障碍[J].广州医药,2024,55(11):1308-1313,6.
