华东师范大学学报（自然科学版）Issue(6)：86-98,13.DOI:10.3969/j.issn.1000-5641.2024.06.008
中国河口沉积物抗生素及抗性基因地理格局和驱动机制
Geographical pattern and driving mechanism of antibiotics and antibiotic resistance genes in estuarine sediment of China
摘要
Abstract
Estuaries are important convergence areas of antibiotic resistance genes(ARGs),but the geographical pattern and main drivers of ARGs in estuarine environments are poorly understood.Therefore,high-throughput quantitative polymerase chain reaction(HT-qPCR)was used to study the prevalence of ARGs in 16 estuaries of China in dry and wet seasons,and statistical analysis was utilized to reveal the influence of various factors on the prevalence of ARGs.The results showed that the abundance of ARGs was higher in the dry season than the wet season,and the abundance of ARGs increased with latitude.Human activities,mobile genetic elements,gut microbes,antibiotic concentrations,physicochemical properties,and climate variables had significant effects on the prevalence of ARGs.Climate variables and human activities had the most significant influence on ARGs.The most important climate variable affecting ARGs was temperature,with an increasing temperature reducing the abundance of ARGs.This study confirmed that human activities and climate factors jointly drive the changes in ARG abundance in estuaries.These findings provide a basis for the development of control policies for ARGs in the context of climate change and socio-economic development in the future.关键词
抗生素/抗生素抗性基因/河口沉积物/人类活动/气候变量Key words
antibiotics/antibiotic resistance genes/estuarine sediment/human activities/climate variables分类
天文与地球科学引用本文复制引用
尹国宇,郑栋升,李晔,黄晔,刘敏..中国河口沉积物抗生素及抗性基因地理格局和驱动机制[J].华东师范大学学报（自然科学版）,2024,(6):86-98,13.基金项目
国家重点研发计划青年科学家项目(2022YFC3105800) （2022YFC3105800）
国家自然科学基金(42230505,42206148,42476153) （42230505,42206148,42476153）
