华西口腔医学杂志2024，Vol.42Issue(6)：689-698,10.DOI:10.7518/hxkq.2024.2024262
基于口腔特殊环境的水凝胶创面敷贴设计策略
Design strategy of hydrogel wound dressings based on oral special environment
摘要
Abstract
Oral wounds caused by injuries,surgeries,diseases,and chemical irritations bring pain to the patient and increase the risk of infection.Effective wound protection and repair are crucial for improving patients'quality of life and maintaining oral health.Wound dressings provide ideal healing conditions by isolating the wound from the oral environ-ment.However,in the highly moist,microbiologically rich environment of the oral cavity,maintaining the stability of wound dressings remains a considerable challenge.Hy-drogels show promising prospects for oral applications and are gradually becoming a research hotspot for ad-dressing the challenges of oral wound protection and re-pair due to their excellent biocompatibility and versatile performance.In this paper,the current design strategies of hydrogel wound dressings that overcome the unique oral environment,achieve sustained adhesion and fulfill their functions are reviewed to provide new insights for the de-sign of ideal oral wound barrier materials.关键词
口腔创面/水凝胶敷贴/湿态粘接/机械性能/药物控释Key words
oral wounds/hydrogel dressing/wet adhesion/mechanical properties/controlled drug release sys-tems分类
医药卫生引用本文复制引用
许瑞,潘钊,邹多宏..基于口腔特殊环境的水凝胶创面敷贴设计策略[J].华西口腔医学杂志,2024,42(6):689-698,10.基金项目
National Natural Science Foundation of China(92368111,32171347) （92368111,32171347）
Training Plan for Health Disci-pline Leaders of Shanghai Municipal Health Commission(2022XD038) （2022XD038）
Biomaterials and Regenerative Medicine Insti-tute Cooperative Research Project,Shanghai Jiao Tong University School of Medicine(2022LHA04) （2022LHA04）
Original Explora-tion Project of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(JYYC007) 国家自然科学基金(92368111,32171347) （JYYC007）
上海市卫生健康委员会卫生健康学科带头人培养计划(2022XD038) （2022XD038）
上海交通大学医学院生物材料与再生医学研究院联合攻关重点项目(2022LHA04) （2022LHA04）
上海交通大学医学院附属第九人民医院原创探索项目(JYYC007) （JYYC007）
