华西口腔医学杂志2024，Vol.42Issue(6)：706-715,10.DOI:10.7518/hxkq.2024.2024315
生物源性钙磷灰石尺寸引发的骨仿生层级演变及其骨凝血免疫效应
Hierarchical evolution of bone biomimicry and osteo-coagulo-immunomodulation induced by the size of biological hydroxyapatite
摘要
Abstract
Biological hydroxyapatite(BHA)is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity.The clinical application of mateiral size is based on the principle of bone defect area adaptation,which contributes to diversity of BHA sizes.However,different sizes correspond to different hierarchi-cal levels of bone biomimicry.As the size changes,the bone biomimicry hierarchy evolves accordingly and influences the process of bone repair and regeneration through osteo-coagulo-immunomodulation,leading to unstable bone graft outcomes.Therefore,this paper reviews the size effect of clinical BHA,analyzes the multilevel structure of natural bone,proposes the evolution of bone biomimetic hierarchy triggered by the size of BHA,and further analyzes the size-media-ted osteo-coagulo-immunomodulation.Based on the hierarchical levels of bone and its osteo-coagulo-immunomodula-tion effect,we provide a new understanding of the biolog-ical principle of the size effect of biomaterials and a theo-retical basis for the basic research and clinical application of different size BHA materials.关键词
生物源性钙磷灰石/仿生层级演变/骨凝血免疫/材料尺寸效应Key words
biological hydroxyapatite/biomimetic hierarchical evolution/osteo-coagulo-immunomodula-tion/material size effect分类
医药卫生引用本文复制引用
许洁芸,赵原,刘浩州,尹靖元,陈泽涛..生物源性钙磷灰石尺寸引发的骨仿生层级演变及其骨凝血免疫效应[J].华西口腔医学杂志,2024,42(6):706-715,10.基金项目
Guangdong Province Scientific and Technological Funds(2023A 0505050138) （2023A 0505050138）
National Natural Science Foundation of China(82071167) （82071167）
Science and Technology Program of Guangzhou(2024A04J6323) （2024A04J6323）
Postdoctoral Fel-lowship Program of China Postdoctoral Science Foundation(GZC20233280) 广东省科技计划项目(2023A0505050138) （GZC20233280）
国家自然科学基金面上项目(82071167) （82071167）
广州市科技计划项目(2024A04-J6323) （2024A04-J6323）
国家资助博士后研究人员计划(GZC20233280) （GZC20233280）
