华西口腔医学杂志2024，Vol.42Issue(6)：778-786,9.DOI:10.7518/hxkq.2024.2024130
口腔癌患者术后低钾血症预测模型的构建及验证
Construction and verification of prediction model for postoperative hypokalemia in patients with oral cancer
摘要
Abstract
Objective This study aimed to explore the risk factors of postoperative hypokalemia in patients with oral cancer and to provide a basis for preventing and controlling postoperative hypokalemia.Methods We included 366 pa-tients undergoing oral cancer surgery in the Department of Head and Neck Oncology,West China Hospital of Stomatolo-gy,Sichuan University from January 2022 to August 2022.Univariate and multivariate analyses were used to determine the risk factors of postoperative hypokalemia.The receiver operation characteristic(ROC)curve was used to quantify the effectiveness of the factors.A nomogram of the risk factors for postoperative hypokalemia in oral cancer patients was de-veloped and validated.Results A total of 224 patients(61.20％)had postoperative hypokalemia,the lowest serum po-tassium level(3.50±0.35)mmol/L on the 4th day after surgery,and the highest incidence of hypokalemia(54.68％).Vari-ables with P＜0.05 in the univariate analysis were quantified by ROC curve followed by multivariate logistic regression analysis.Results showed an independent correlation with postoperative hypokalemia as follows:preoperative se-rum potassium＜3.87 mmol/L(P=0.008),preoperative se-rum calcium＜2.31 mmol/L(P=0.033),preoperative PNI＜49.16(P=0.032),postoperative drainage volume＞264.25 mL(P=0.002).The above variables were constructed into a postoperative hypokalemia risk nomogram and verified,and a good degree of fit was found.Conclusion The indepen-dent risk factors for postoperative hypokalemia in patients with oral cancer were as follows:preoperative serum potassi-um＜3.87 mmol/L,preoperative serum calcium＜2.31 mmol/L,preoperative PNI＜49.16,and postoperative drainage vol-ume＞264.25 mL.Clinical attention should be paid to managing the above high-risk patients.Preventive potassium sup-plementation should be performed as soon as possible to reduce hypokalemia occurrence.关键词
口腔癌/低钾血症/预后营养指数/影响因素/列线图Key words
oral cancer/hypokalemia/prognostic nutritional index/influencing factor/nomogram分类
医药卫生引用本文复制引用
王光满,毕小琴,汤晓雪..口腔癌患者术后低钾血症预测模型的构建及验证[J].华西口腔医学杂志,2024,42(6):778-786,9.基金项目
Medical Research Project of Chengdu(2022015) 成都市医学科研课题(2022015) （2022015）
