解放军医学杂志2024，Vol.49Issue(11)：1259-1265,7.DOI:10.11855/j.issn.0577-7402.0048.2024.0909
无功能垂体腺瘤的临床管理策略
Clinical management strategies for non-functional pituitary adenomas
摘要
Abstract
Non-functional pituitary adenomas(NFPAs)are relatively common intracranial sellar tumors.The diagnostic rate of NFPAs has significantly increased in recent years due to the widespread application of computed tomography(CT)and magnetic resonance imaging(MRI)in clinical practice.NFPAs do not exhibit increased biochemical hormone secretion,so they may not present with obvious clinical manifestations.However,as the tumor grows,it can cause mass effect symptoms,such as headache,visual impairment,and related pituitary target gland dysfunction,and even life-threatening pituitary stroke.The evaluation of pituitary function in patients with NFPAs and the selection of treatment plans require close collaboration and scientific management by a multidisciplinary team.The genetic and epigenetic mechanisms underlying the occurrence and development of NFPAs have not yet been fully elucidated.New treatment strategies may be developed through technologies such as whole-genome sequencing combined with chromatin structure analysis.This review systematically summarizes the research progress in epidemiology,histopathology,clinical diagnosis,treatment,and prognosis of NFPAs,aiming to provide reference and guidance for clinical management.关键词
无功能垂体腺瘤/垂体功能/经鼻碟手术/放射治疗/多巴胺受体激动剂Key words
non-functional pituitary adenomas/pituitary function/transsphenoidal surgery/radiation therapy/dopamine receptor agonists分类
医药卫生引用本文复制引用
徐茜,韩香,赵静,鞠海兵..无功能垂体腺瘤的临床管理策略[J].解放军医学杂志,2024,49(11):1259-1265,7.基金项目
This work was supported by the Yunnan Province Xingdian Talent Medical and Health Talent Project(XDYC-YLWS-2023-0098) 云南省兴滇英才医疗卫生人才项目(XDYC-YLWS-2023-0098) （XDYC-YLWS-2023-0098）
