解放军医学杂志2024，Vol.49Issue(11)：1295-1301,7.DOI:10.11855/j.issn.0577-7402.0113.2024.0717
红细胞体积分布宽度变异系数和血清IL-11、IL-31在间质性肺疾病诊断中的应用价值
The clinical value of red blood cell volume distribution width coefficient of variation and serum IL-11 and IL-31 in the diagnosis of interstitial lung disease
摘要
Abstract
Objective To explore the clinical value of red blood cell volume distribution width coefficient of variation(RDW-CV),serum interleukin-11(IL-11)and interleukin-31(IL-31)in the diagnosis of interstitial lung disease(ILD).Methods Prospectively selected 46 ILD patients admitted to the Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Chengde Medical University from November 2022 to October 2023 were set as ILD group,40 patients with community-acquired pneumonia(CAP)as CAP group,and 35 healthy examiners as control group.The ILD group was further divided into idiopathic interstitial pneumonia(IIP)subgroup(n=30)and connective tissue disease-related ILD(CTD-ILD)subgroup(n=16)based on clinical diagnosis.General and clinical data of each group were recorded,and RDW-CV and serum IL-11 and IL-31 levels were detected in each group.The ILD group was tested for alveolar arterial oxygen pressure difference(AaDO2)and arterial blood oxygen pressure(PaO2),and calculated the oxygenation index(OI).The correlation between the levels of RDW-CV,IL-11 and IL-31 and the severity of ILD were analyzed to explore the value of the above indicators in the clinical diagnosis of ILD and the differential diagnosis of different types of ILD.Results Compared with control group,there was no statistically significant difference in general information such as age,gender,smoking history,and complications between the ILD and CAP groups(P>0.05);RDW-CV,absolute values of neutrophil count(NEUT),and serum IL-11 and IL-31 levels in ILD group were significantly increased(P<0.05).Compared with CAP group,the levels of RDW-CV and serum IL-11,IL-31 in ILD group were increased,while the level of serum C-reactive protein(CRP)was decreased,with statistically significant differences(P<0.05).Correlation analysis results showed that RDW-CV and serum IL-31 in ILD patients were negatively correlated with OI(P<0.05),and positively correlated with AaDO2(P<0.05).The area under the ROC curves(AUC)of RDW-CV and serum IL-11,IL-31 single and combined applications for diagnosing ILD were 0.770,0.666,0.646,and 0.854,respectively(P<0.05).The AUC of serum IL-11 for differential diagnosis of CTD-ILD and IIP was 0.727(95%CI 0.580-0.874),with sensitivity of 62.5%and specificity of 73.3%(P<0.05).Conclusions RDW-CV and serum IL-31 have certain value in assessing the severity of ILD.RDW-CV and serum IL-11 and IL-31 have certain value in the diagnosis of ILD.Serum IL-11 has certain value in the differential diagnosis between CTD-ILD and IIP.关键词
间质性肺疾病/红细胞体积分布宽度变异系数/白细胞介素-11/白细胞介素-31Key words
interstitial lung disease/red blood cell volume distribution width/interleukin-11/interleukin-31分类
医药卫生引用本文复制引用
郭鑫龙,赵志伟,庞桂芬,杨林瀛..红细胞体积分布宽度变异系数和血清IL-11、IL-31在间质性肺疾病诊断中的应用价值[J].解放军医学杂志,2024,49(11):1295-1301,7.基金项目
This work was supported by the Project of Hebei Key Laboratory of Panvascular Diseases(SZX202306),and the Talent Training Program on Clinical Medicine Founded by Government of Hebei Province[Ji Health(2021)No.9] 河北省泛血管疾病重点实验室项目(SZX202306) （SZX202306）
河北省政府资助临床医学人才培养项目[翼卫办科教(2021)9号] （2021）
