昆明医科大学学报2024，Vol.45Issue(11)：16-21,6.DOI:10.12259/j.issn.2095-610X.S20241103
HOXD-AS2、MIR3142HG基因多态性与宫颈上皮内瘤变的相关性
The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia
摘要
Abstract
Objective To explore the association of HOXD-AS2 and MIR3142HG gene polymorphism with cervical intraepithelial neoplasia(CIN).Methods Two single nucleotide polymorphisms(SNPs)located in HOXD-AS2(rs1348808)and located in MIR3142HG(rs2431099)were selected using bioinformatics tools.The two candidate SNPs were genotyped in 976 healthy individuals and 419 patients with CIN using the TaqMan probe method for genotyping,and the association with CIN were analyzed.Results rs1348808 C allele might be the protective factor for CIN3 as well as the progression from CIN2 to CIN3(OR=0.77,95%CI:0.63～0.94;OR=0.57,95%CI:0.37～0.90).Similarly,rs2431099 A allele might be the protective factor of CIN2(OR=0.50,95%CI:0.31～0.80).Conclusion HOXD-AS2 and MIR3142HG gene polymorphisms might be associated with CIN.关键词
宫颈上皮内瘤变/长链非编码RNA/单核苷酸多态性/MAPK信号通路Key words
Cervical intraepithelial neoplasia/lncRNA/SNP/MAPK signaling pathway分类
医药卫生引用本文复制引用
陈雪雅,许金美,李智,梁燕,姚宇峰,何凤权,严志凌..HOXD-AS2、MIR3142HG基因多态性与宫颈上皮内瘤变的相关性[J].昆明医科大学学报,2024,45(11):16-21,6.基金项目
云南省基础研究计划基金资助项目(202201AY070001-139) （202201AY070001-139）
云南省"兴滇英才"支持计划产业创新人才基金资助项目(XDYC-CYCX-2023-0074) （XDYC-CYCX-2023-0074）
