昆明医科大学学报2024，Vol.45Issue(11)：149-154,6.DOI:10.12259/j.issn.2095-610X.S20241121
艾滋病抗病毒治疗患者代谢综合征发生现况及影响因素
Analysis of the Current Status and Influencing Factors of Metabolic Syndrome in Patients Undergoing Antiretroviral Therapy for AIDS
摘要
Abstract
Objective To investigate the current status of metabolic syndrome(MS)in ART patients and analyze its influencing factors.Methods Data from 1972 ART patients were collected and the prevalence of MS was determined according to the diagnostic guidelines.T-tests,chi-square tests,and rank-sum tests were used to compare the differences in the related factors,and the logistic regression was used to analyze the influencing factors.Results Among these patients,495(25.05%)met the diagnostic criteria for MS.The risk of MS in males was 2.045 times higher than that in females(P=0.001).Patients with elementary or lower education had a higher risk of MS than those with the secondary(P=0.001)or higher education(P<0.001).The risk of developing MS for those over 40 years old was 8.819 times higher than those under 40 years old(P<0.001).Smokers had a 1.565 times higher risk of MS compared to non-smokers(P<0.001).Patients with BMI≥25 kg/m2(P<0.001),fasting glucose≥6.1 mmol/L(P<0.001),TG≥1.7 mmol/L(P<0.001),HDL-C<1.04 mmol/L(P<0.001),and blood pressure≥130/85 mmHg(P<0.001)were at the higher risk of MS.Pairwise comparisons of the patients using different ART regimens showed that those using integrase inhibitors had a higher incidence of MS(χ2=17.278,P<0.001).Conclusion The prevalence of metabolic syndrome is high among the patients undergoing antiretroviral therapy for AIDS.More interventions and recommendations should be provided to actively reduce and prevent the occurrence of metabolic syndrome.Lifestyle interventions should be a critical part of managing AIDS patients.The focus is on monitoring the blood pressure,blood sugar,and lipid abnormalities,and taking corresponding measures for individualized treatment and management so as to minimize the occurrence of metabolic syndrome.关键词
艾滋病病毒/艾滋病/代谢综合征/影响因素Key words
HIV AIDS/Metabolic syndrome/Current status/Influencing factors分类
医药卫生引用本文复制引用
田波,刘俊,金永梅,李海雯,李重熙,张伟,关玮,陈海云,薛琪,杨惠榕..艾滋病抗病毒治疗患者代谢综合征发生现况及影响因素[J].昆明医科大学学报,2024,45(11):149-154,6.基金项目
云南省科技厅-大理大学地方高校联合专项基金资助项目(202001BA070001-194) （202001BA070001-194）
昆明市卫生科技基金资助项目(2022-03-08-013,2022-03-08-007) （2022-03-08-013,2022-03-08-007）
