临床误诊误治2024，Vol.37Issue(20)：87-90,4.DOI:10.3969/j.issn.1002-3429.2024.20.018
乌司他丁联合序贯透析及持续血液滤过治疗重症急性胰腺炎脓毒症休克的临床效果
Clinical Effect of Ulinastatin Combined with Sequential Dialysis and Con-tinuous Hemofiltration on Severe Acute Pancreatitis and Septic Shock
摘要
Abstract
Objective To analyze the effect and safety of Ulinastatin combined with sequential dialysis and continu-ous hemofiltration in the treatment of severe acute pancreatitis and septic shock.Methods From January 2021 to December 2023,76 patients with severe acute pancreatitis and septic shock were selected and divided into groups according to different treatment methods.Thirty-eight patients in the control group received Ulinastatin treatment,and 38 patients in the observation group was supplemented with sequential dialysis and continuous hemofiltration treatment on the basis of the control group.The treatment status,adverse reactions,acute physiological and chronic health evaluation scoring systemⅡ(APACHEⅡ),inter-leukin-6(IL-6),interleukin-8(IL-8),high mobility group box-1 protein(HMGB1)and obestatin levels before and after treatment were compared between the two groups.Results Recovery time of blood amylase,gastrointestinal function and urine amylase and the length of hospital stay in the observation group were shorter than those in the control group,and the in-cidence of adverse reactions was lower than that in the control group(P＜0.05).At 12,24 and 72 h after treatment,APACHEⅡ scores in the two groups were lower than those before treatment,and the observation group had lower scores than the control group(P＜0.05).After treatment,the levels of IL-6,IL-8,HMGB1 and obestatin in the two groups were lower than those before treatment,and the observation group had lower levels than the control group(P＜0.05).Conclusion Uli-nastatin combined with sequential dialysis and continuous hemofiltration is effective in the treatment of severe acute pancreatitis and septic shock,which can reduce adverse reactions and APACHEⅡscores,and alleviate inflammatory reactions,thus im-proving the prognosis of patients and enhancing drug safety.关键词
胰腺炎,急性/脓毒症休克/乌司他丁/序贯透析/血液滤过/白细胞介素-6/高迁移率族蛋白B1/肥胖抑制素Key words
Pancreatitis,acute/Septic shock/Ulinastatin/Sequential dialysis/Hemofiltration/Interleukin-6/High mobility group box-1 protein/Obestatin分类
医药卫生引用本文复制引用
韩文君,李晓凡,李欣,史丽娜,林丽娜,李有亮,王艳,徐丹丹..乌司他丁联合序贯透析及持续血液滤过治疗重症急性胰腺炎脓毒症休克的临床效果[J].临床误诊误治,2024,37(20):87-90,4.基金项目
河北省医学科学研究重点课题计划项目(20221888) （20221888）
