皮肤性病诊疗学杂志2024，Vol.31Issue(11)：741-746,6.DOI:10.3969/j.issn.1674-8468.2024.11.003
进展期寻常型银屑病患者血清sST2、CCL19水平及其临床意义
Serum levels of sST2 and CCL19 and their clinical significance in patients with psoriasis vulgaris at the progressive stage
摘要
Abstract
Objective To investigate the serum levels of soluble suppression of tumorigenicity 2(sST2)and C-C chemokine ligand 19(CCL19)in patients with psoriasis vulgaris(PV)at the progressive stage and their clinical significance.Methods From January 2021 to June 2023,86 psoriatic patients at the progressive stage were enrolled.The patients were divided into mild,mod-erate,and severe groups according to the severity of disease.A total of 86 healthy individuals who underwent routine physical examination were enrolled during the same period.Enzyme linked im-munosorbent assay(ELISA)was applied to detect the levels of sST2,CCL19,interleukin-17A,IL-21,IL-22,and IL-23 in the serum of both groups.Pearson and Spearman's methods were used to analyze the correlation of serum levels of sST2 and CCL19 with inflammatory cytokines and pso-riasis area and severity index(PASI),respectively.The influencing factors of PV were analyzed using multivariate logistic regression.ROC curve was plotted to analyze the diagnostic value of ser-um levels of sST2 and CCL19 for PV.Results The serum levels of sST2,CCL19,IL-17A,IL-21,IL-22,and IL-23 in the study group were significantly higher than that in the control group(P＜0.05).The serum levels of sST2,CCL19,IL-17A,IL-21,IL-22,and IL-23 were positively as-sociated with disease severity(P＜0.05).Pearson's correlation analysis showed that the serum lev-el of sST2 was positively correlated with CCL19(P＜0.05),and both sST2 and CCL19 levels were positively correlated with the levels of IL-17A,IL-21,IL-22,and IL-23(P＜0.05).More-over,Spearman's correlation indicated that the serum levels of sST2 and CCL19 were positively correlated with PASI(P＜0.05).Multivariate logistic regression analysis revealed that the serum levels of sST2 and CCL19 were risk factors for PV(P＜0.05).According to the ROC curve,the combination of serum levels of sST2 and CCL19 was superior to individual marker in the diagnosis of PV(Z=2.71,Z=2.70,P＜0.05).Conclusions The serum levels of sST2 and CCL19 are greatly elevated in patients with PV at the progressive stage,and the combination of these two bio-markers can be helpful in the diagnosis of PV at the progressive stage.关键词
寻常型银屑病/进展期/可溶性致癌抑制因子2/趋化因子配体19Key words
psoriasis vulgaris/progressive stage/soluble suppression of tumorigenicity 2/C-C chemokine ligand 19引用本文复制引用
李舒,丁伟芳,胡耀刚,曹大勇..进展期寻常型银屑病患者血清sST2、CCL19水平及其临床意义[J].皮肤性病诊疗学杂志,2024,31(11):741-746,6.基金项目
河南省医学科技攻关计划项目(LHGJ20200698) （LHGJ20200698）
