进展期寻常型银屑病患者血清sST2、CCL19水平及其临床意义OA
Serum levels of sST2 and CCL19 and their clinical significance in patients with psoriasis vulgaris at the progressive stage
目的 探究进展期寻常型银屑病(PV)患者血清中的可溶性致癌抑制因子2(sST2)、趋化因子配体19(CCL19)水平及其临床意义.方法 选取2021年1月-2023年6月在本院就诊的进展期PV患者86例作为研究组,将患者根据病情严重程度分为轻度、中度和重度组.选择同期常规体检结果正常的健康体检者86例作为对照组.采用酶联免疫吸附法检测两组血清中sST2、CCL19、白细胞介素(IL)-17A、IL-21、IL-22、IL-23水平.采用Pearson法分析血清sST2、CCL19水平的相关性及二者与炎性因子水平的相关性,Spearman法分析血清sST2、CCL19水平与PASI的相关性;多因素Logistic回归分析PV的影响因素;绘制ROC曲线分析血清sST2、CCL19水平对PV的诊断价值.结果 研究组血清sST2、CCL19、IL-17A、IL-21、IL-22 和 IL-23 水平显著高于对照组(P＜0.05).sST2、CCL19、IL-17A、IL-21、IL-22和IL-23在轻度、中度和重度组患者血清中的水平依次升高(P＜0.05).Pearson相关性分析表明患者血清中sST2水平与CCL19水平呈正相关(P＜0.05),二者与IL-17A、IL-21、IL-22和IL-23水平均呈正相关(均P＜0.05).Spearman相关性分析表明,患者血清中sST2、CCL19水平与PASI评分均呈正相关(均P＜0.05).多因素Logistic回归分析显示sST2、CCL19为影响PV的危险因素(P＜0.05).血清sST2、CCL19水平联合诊断优于各自单独诊断PV(Z=2.71、Z=2.70,均 P＜0.05).结论 进展期PV患者血清中的sST2、CCL19水平显著升高,联合二者可为进展期PV的判定提供重要参考.
Objective To investigate the serum levels of soluble suppression of tumorigenicity 2(sST2)and C-C chemokine ligand 19(CCL19)in patients with psoriasis vulgaris(PV)at the progressive stage and their clinical significance.Methods From January 2021 to June 2023,86 psoriatic patients at the progressive stage were enrolled.The patients were divided into mild,mod-erate,and severe groups according to the severity of disease.A total of 86 healthy individuals who underwent routine physical examination were enrolled during the same period.Enzyme linked im-munosorbent assay(ELISA)was applied to detect the levels of sST2,CCL19,interleukin-17A,IL-21,IL-22,and IL-23 in the serum of both groups.Pearson and Spearman's methods were used to analyze the correlation of serum levels of sST2 and CCL19 with inflammatory cytokines and pso-riasis area and severity index(PASI),respectively.The influencing factors of PV were analyzed using multivariate logistic regression.ROC curve was plotted to analyze the diagnostic value of ser-um levels of sST2 and CCL19 for PV.Results The serum levels of sST2,CCL19,IL-17A,IL-21,IL-22,and IL-23 in the study group were significantly higher than that in the control group(P＜0.05).The serum levels of sST2,CCL19,IL-17A,IL-21,IL-22,and IL-23 were positively as-sociated with disease severity(P＜0.05).Pearson's correlation analysis showed that the serum lev-el of sST2 was positively correlated with CCL19(P＜0.05),and both sST2 and CCL19 levels were positively correlated with the levels of IL-17A,IL-21,IL-22,and IL-23(P＜0.05).More-over,Spearman's correlation indicated that the serum levels of sST2 and CCL19 were positively correlated with PASI(P＜0.05).Multivariate logistic regression analysis revealed that the serum levels of sST2 and CCL19 were risk factors for PV(P＜0.05).According to the ROC curve,the combination of serum levels of sST2 and CCL19 was superior to individual marker in the diagnosis of PV(Z=2.71,Z=2.70,P＜0.05).Conclusions The serum levels of sST2 and CCL19 are greatly elevated in patients with PV at the progressive stage,and the combination of these two bio-markers can be helpful in the diagnosis of PV at the progressive stage.
李舒;丁伟芳;胡耀刚;曹大勇
郑州市第七人民医院,河南 郑州 450000郑州市第七人民医院,河南 郑州 450000郑州市第七人民医院,河南 郑州 450000郑州市第七人民医院,河南 郑州 450000
寻常型银屑病进展期可溶性致癌抑制因子2趋化因子配体19
psoriasis vulgarisprogressive stagesoluble suppression of tumorigenicity 2C-C chemokine ligand 19
《皮肤性病诊疗学杂志》 2024 (11)
741-746,6
河南省医学科技攻关计划项目(LHGJ20200698)
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