IL-17A抑制剂治疗乌司奴单抗诱发的脓疱型银屑病1例OA

We report a case of ustekinumab-induced pustular psoriasis treated with IL-17A in-hibitor.A 51-year-old female presented with red plaques and scales for 20 years,with aggravation and pustules for over 10 days.The patient was previously diagnosed with plaque psoriasis,and poorly responded to systemic medications.After ruling out contraindications,the patient was sub-cutaneously given 45 mg of ustekinumab,resulting in clearance of the skin lesion.But erythema and scales with pustules appeared all over the body after the fourth treatment.Physical examina-tion revealed scattered red plaques covered with white-silver scales,and Auspitz sign(+)on the head and face.The trunk and limbs were scattered with large erythematous patches and erythema-tous plaques,covered with various size of dense pustules,in a target-shape with a brown center.Some pustules merged to pus-lake.Pustules with erosive surface were scattered on the vulvar mu-cosa.Nails appeared thimble-like with nail plate thickening.Histopathology showed hyperkerato-sis,parakeratosis,thinning or disappearance of granular layer,psoriasis-like epidermal hyperpla-sia,Munro and Kogoj microabscesses,papillary dermal edema,vascular dilation,and perivascu-lar lymphocytic infiltration.Diagnosis was pustular psoriasis.After the treatment with topical corti-costeroids and 160 mg of ixekizumab,the rashes subsided within 3 days.Afterwards,patient was treated with ixekizumab according to the manufacturer's instruction,without the development of new lesion during 1-year follow-up.