皮肤性病诊疗学杂志2024，Vol.31Issue(11)：783-788,6.DOI:10.3969/j.issn.1674-8468.2024.11.010
非编码RNA在皮肤光老化中的作用进展
Role of non-coding RNAs in skin photoaging
摘要
Abstract
Skin photoaging,a phenomenon of premature skin aging due to prolonged exposure to ultraviolet(UV)radiation,manifests as wrinkles,loss of skin elasticity,pigmentation disor-ders,and age spots.Non-coding RNAs(ncRNAs),including microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),play a crucial role in regulating gene expression and the development of skin photoaging.This review summarizes the molecular mecha-nisms of specific ncRNAs(such as miR-34a,miR-134,miR-1246,lncRNA H19-miR-296-5p-IGF2,lncRNA PVT1-miR-551b-3p-AQP3,lncRNAMeg3-miR-93-5p-epiregulin,circ-COL3A1-859267 and circ-0011129)in skin photoaging.Additionally,the review discusses the potential application of ncRNA-based therapies in photoaging,as well as the current challenges and future research directions.关键词
皮肤光老化/ncRNA/miRNA/lncRNA/circRNA/炎症反应/氧化应激/细胞外基质重塑Key words
skin photoaging/non-coding RNA/miRNA/lncRNA/circRNA/inflam-matory response/oxidative stress/extracellular matrix remodeling引用本文复制引用
何泽枝,陈嘉珍,吴慧,沈郝佳,李润祥,朱慧兰..非编码RNA在皮肤光老化中的作用进展[J].皮肤性病诊疗学杂志,2024,31(11):783-788,6.基金项目
广州市科技计划项目(2024A03J0559) （2024A03J0559）
