西南医科大学学报2024，Vol.47Issue(6)：481-487,7.DOI:10.3969/j.issn.2096-3351.2024.06.005
前列腺癌骨转移机制研究进展
Research progress on the mechanisms behind prostate cancer bone metastasis
摘要
Abstract
Bone metastasis is a prominent manifestation in the advanced stages of prostate cancer and a significant cause of mor-tality among prostate cancer patients.This review examined the malignant physiological behavior of prostate cancer and its bone metas-tasis mechanisms.It explored the processes by which primary prostate cancer develops tumor subpopulations with bone metastatic phe-notypes and the factors that promote various stages of the metastatic cascade.The clonal evolution theory explains how prostate cancer cells develop subclones with varying metastatic potentials through genetic mutations.The epithelial-mesenchymal transition(EMT)theory and the role of matrix metalloproteinases(MMPs)have been shown to elucidate the processes of local invasion and intravasation.The seed and soil theory,along with the circulating tumor cell(CTC)theory,have shed light on how prostate cancer cells colonize the bone marrow and form micrometastases.Additionally,the tumor microenvironment theory has described how reactivated prostate cancer cells interact with other cells to establish metastatic lesions.By reviewing related research findings,this paper aimed to provide theoreti-cal support for further research on the mechanisms of prostate cancer metastasis and to offer references for the optimization of clinical treatment strategies.关键词
前列腺癌/骨转移/转移机制/克隆进化/上皮-间质转化/循环肿瘤细胞/肿瘤微环境Key words
Prostate cancer/Bone metastasis/Metastatic mechanisms/Clonal evolution/Epithelial-mesenchymal transition/Circulating tumor cells/Tumor microenvironment分类
医药卫生引用本文复制引用
邓龙昕,周睿,吴涵,何煌,陈锐..前列腺癌骨转移机制研究进展[J].西南医科大学学报,2024,47(6):481-487,7.基金项目
国家自然科学基金面上项目(82272905) （82272905）
上海市科学技术委员会自然科学基金面上项目(22ZR1478000) （22ZR1478000）
