生命科学仪器2024，Vol.22Issue(6)：97-98,101,3.DOI:10.11967/2024221233
白蛋白紫杉醇联合吉西他滨与替吉奥联合吉西他滨治疗转移性胰腺癌的疗效及安全性对比
Comparison of Efficacy And Safety of Albumin Paclitaxel Combined with Gemcitabine And S-1 Combined with Gemcitabine in the Treatment of Metastatic Pancreatic Cancer
王雅 1卢义晨2
作者信息
- 1. 湖南省肿瘤医院(中南大学湘雅医学院附属肿瘤医院)肺/胃肠内科,湖南 长沙 410001
- 2. 湖南省人民医院(湖南师范大学附属第一医院)肿瘤二科,湖南 长沙 410016
- 折叠
摘要
Abstract
Objective:To compare and analyze the clinical efficacy and safety of albumin paclitaxel combined with gemcit-abine and S-1 combined with gemcitabine in the treatment of metastatic pancreatic cancer.Methods:Seventy-five patients with metastatic pancreatic cancer diagnosed in Hunan Cancer Hospital from January 2021 to January 2024 were divided into two groups according to the treatment Methods:the treatment group of albumin paclitaxel combined with gemcitabine was AG group,with 38 cases in total;The treatment group of S-1 combined with gemcitabine was GS group,with 37 cases in total.The therapeutic effects and adverse reactions of the two groups were compared.Results:Both groups completed at least 2 cycles of chemotherapy.The ORR of chemotherapy in AG group was 15.8%,and the DCR was 50.0%.The ORR and DCR of chemotherapy in GS group were 7.4%and 18.5%respectively.Comparison of ORR of chemotherapy between the two groups,P>0.05;However,the DCR of the two groups was significantly higher in AG group than in GS group,P<0.05.The incidence of bone marrow suppression in GS group Ⅰ～Ⅱ was 67.6%,and that in AG group was 76.3%,P>0.05.The incidence of digestive tract reaction in GS group was 100%,and that in AG group was 100%,compared with each other,P>0.05.There was no chemotherapy-related death in both groups,P>0.05.Conclusion:Gemcitabine com-bined with albumin paclitaxel in the treatment of metastatic pancreatic cancer is significantly better than gemcitabine com-bined with S-1 in disease control,and the adverse reactions have not increased significantly.关键词
转移性胰腺癌/白蛋白紫杉醇/替吉奥/吉西他滨/不良反应Key words
Metastatic pancreatic cancer/Albumin paclitaxel/Tegeol/Gemcitabine/Efficacy/Adverse reactions分类
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王雅,卢义晨..白蛋白紫杉醇联合吉西他滨与替吉奥联合吉西他滨治疗转移性胰腺癌的疗效及安全性对比[J].生命科学仪器,2024,22(6):97-98,101,3.
