Extracellular vesicles in anti-tumor drug resistance:Mechanisms and therapeutic prospectsOA
Extracellular vesicles in anti-tumor drug resistance:Mechanisms and therapeutic prospects
Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic pathways.However,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable insights.EVs are membrane-bound particles secreted by all cells,mediating cell-to-cell communication.They contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other cells.Notably,EVs are increasingly recognized as regulators in the resistance to anti-cancer drugs.This review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even radiotherapy.Detecting EV-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug resistance.Additionally,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug resistance.We highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV subpopulations.These efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.
Hao-Yang Cheng;Guang-Liang Su;Yu-Xuan Wu;Gang Chen;Zi-Li Yu
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School & Hospital of Stomatology,Wuhan University,Wuhan,430079,ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School & Hospital of Stomatology,Wuhan University,Wuhan,430079,China||Department of Oral and Maxillofacial Surgery,School and Hospital of Stomatology,Wuhan University,Wuhan,430079,China||TaiKang Center for Life and Medical Sciences,Wuhan University,Wuhan,430071,China||Frontier Science Center for Immunology and Metabolism,Wuhan University,Wuhan,430071,ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School & Hospital of Stomatology,Wuhan University,Wuhan,430079,China||Department of Oral and Maxillofacial Surgery,School and Hospital of Stomatology,Wuhan University,Wuhan,430079,China
Extracellular vesicleAnti-Tumor therapyDrug resistanceMechanismsProspects
《药物分析学报（英文）》 2024 (007)
940-954 / 15
This work was supported by the National Natural Science Foundation of China(Grant No.:82341023),the Interdisciplinary Research Project of School of Stomatology,Wuhan University,China(Grant No.:XNJC202305),the Innovative Research Team of High-level Local Universities in Shanghai,China(Grant No.:SHSMU-ZLCX20212300),and Planning Project of Innovation and Entrepre-neurship Training of National Undergraduate of Wuhan University,China(Grant No.:202310486122).
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