Non-coding RNAs as therapeutic targets in cancer and its clinical applicationOA
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.Oncogenes promote cell growth and proliferation,whereas tumor suppressor genes inhibit cell growth and division.The dysregulation of these genes can lead to the development of cancer.Recent studies have focused on non-coding RNAs(ncRNAs),including circular RNA(circRNA),long non-coding RNA(lncRNA),and microRNA(miRNA),as therapeutic targets for cancer.In this article,we discuss the oncogenes and tumor suppressor genes of ncRNAs associated with different types of cancer and their potential as therapeutic targets.Here,we highlight the mechanisms of action of these genes and their clinical applications in cancer treatment.Understanding the molecular mechanisms underlying cancer development and identifying specific therapeutic targets are essential steps towards the development of effective cancer treatments.
Xuejiao Leng;Nianguang Li;Ye Yang;Zhihao Shi;Mengyuan Zhang;Yujing Xu;Jingjing Wang;Ning Ding;Yancheng Yu;Shanliang Sun;Weichen Dai;Xin Xue
National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine,Nanjing,210023,ChinaSchool of Medicine & Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing,210023,ChinaLaboratory of Molecular Design and Drug Discovery,School of Science,China Pharmaceutical University,Nanjing,211198,China
Non-coding RNATherapeutic targetsCancerClinical application
《药物分析学报（英文）》 2024 (007)
983-1010 / 28
This work was financially supported by the National Natural Science Foundation of China(Grant Nos.:81973171,82103985,and 82373710),the National Key Research and Development Program of China(Grant No.:2020YFA0509404),the Natural Science Founda-tion of Jiangsu Provincial Colleges and Universities(Grant No.:21KJB350005),the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(Grant No.:2020YLXK002),Project Funded by the Priority Academic Pro-gram Development of Jiangsu Higher Education Institutions.
评论