An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapyOA
An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy
Microwave thermotherapy(MWTT),as a treatment for tumors,lacks specificity and requires sensitizers.Most reported microwave sensitizers are single metal-organic frameworks(MOFs),which must be loaded with ionic liquids to enhance the performance in MWTT.Meanwhile,MWTT is rarely combined with other treatment modalities.Here,we synthesized a novel Fe-Cu bimetallic organic framework FeCuMOF(FCM)by applying a hydrothermal method and further modified it with methyl…查看全部>>
Xinyang Zhu;Chao He;Longfei Tan;Xun Qi;Meng Niu;Xianwei Meng;Hongshan Zhong
Department of Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province,The First Affiliated Hospital of China Medical University,Shenyang,110001,China||Xixian New Area Rimag Medical Diagnosis Center,Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712099,China c Laboratory of Controllable Preparation and Application of Nanomaterials,Laboratory of Cryogenics,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,ChinaXixian New Area Rimag Medical Diagnosis Center,Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712099,China c Laboratory of Controllable Preparation and Application of Nanomaterials,Laboratory of Cryogenics,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,ChinaDepartment of Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province,The First Affiliated Hospital of China Medical University,Shenyang,110001,China
Microwave thermotherapyMetal organic frameworksGlutathione scavengingMagnetic resonance imagingSynergism
《药物分析学报(英文)》 2024 (007)
1063-1075 / 13
This work was supported by the National Key R&D Program of China(Grant No.:2018YFC0115500),the National Natural Science Foundation of China(Grant No.:U21A20378),Liaoning Revitaliza-tion Talents Program,China(Grant No.:XLYC1802098),the Natural Science Foundation of Shaanxi Provincical Department of Educa-tion,China(Grant No.:21JK0593),and the Key Research and Development Plan of Science and Technology Department of Xia-nyang City,China(Grant No.:L2023-ZDYF-SF-054).We thank Prof.Xiangling Ren,Mr.Zengzhen Chen,and Ms.Qiong Wu from the Technical Institute of Physics and Chemistry,University of Chinese Academy of Sciences and Mr.Dongqi Li and Mr.Qiaozheng Wang from the first Clinical College of China Medical University for helping us complete the experiments.
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