Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosisOA
Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosis
Renal fibrosis is a devastating consequence of progressive chronic kidney disease,representing a major public health challenge worldwide.The underlying mechanisms in the pathogenesis of renal fibrosis remain unclear,and effective treatments are still lacking.Renal tubular epithelial cells(RTECs)maintain kidney function,and their dysfunction has emerged as a critical contributor to renal fibrosis.Cellular quality control comprises several components,including telomere homeostasis,ubiquitin-proteasome system(UPS),autophagy,mitochondrial homeostasis(mitophagy and mitochondrial metabolism),endoplasmic reticulum(ER,unfolded protein response),and lysosomes.Failures in the cellular quality control of RTECs,including DNA,protein,and organelle damage,exert profibrotic functions by leading to senescence,defective autophagy,ER stress,mitochondrial and lysosomal dysfunction,apoptosis,fibro-blast activation,and immune cell recruitment.In this review,we summarize recent advances in un-derstanding the role of quality control components and intercellular crosstalk networks in RTECs,within the context of renal fibrosis.
Yini Bao;Shuosheng Zhang;Gang Cao;Qiyuan Shan;Keda Lu;Qiao Yang;Ying Liang;Haodan Kuang;Lu Wang;Min Hao;Mengyun Peng
School of Pharmacy,Zhejiang Chinese Medical University,Hangzhou,310053,ChinaCollege of Chinese Materia Medica and Food Engineering,Shanxi University of Chinese Medicine,Jinzhong,Shanxi,030600,ChinaSchool of Pharmacy,Zhejiang Chinese Medical University,Hangzhou,310053,China||The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,310009,ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,310009,China
Renal tubular epithelial cellsQuality controlRenal fibrosisTelomere homeostasisAutophagyMitochondria
《药物分析学报（英文）》 2024 (008)
1099-1109 / 11
This work was financially supported by the National Natural Science Foundation of China(Grant No.:82204625),the Natural Science Foundation of Zhejiang Province(Grant Nos.:LQ23H280013 and LZ22H280001),the Chinese Medicine Research Program of Zhejiang Province(Program Nos.:2021ZZ009,2023ZR009,and 2021ZQ023),and the Youth Natural Science Pro-gram of Zhejiang Chinese Medical University(Program No.:2021RCZXZK14).We appreciate the great help from the Pharma-ceutical Research Center and Medical Research Center,Academy of Chinese Medical Sciences,Zhejiang Chinese Medical University.
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