Design of a nanozyme-based magnetic nanoplatform to enhance photodynamic therapy and immunotherapyOA
Design of a nanozyme-based magnetic nanoplatform to enhance photodynamic therapy and immunotherapy
The tumor microenvironment,particularly the hypoxic property and glutathione(GSH)overexpression,substantially inhibits the efficacy of cancer therapy.In this article,we present the design of a magnetic nanoplatform(MNPT)comprised of a photosensitizer(Ce6)and an iron oxide(Fe3O4)/manganese oxide(MnO2)composite nanozyme.Reactive oxygen species(ROS),such as singlet oxygen(1O2)radicals produced by light irradiation and hydroxyl radicals(·OH)produced by catalysis,are therapeutic species.These therapeutic substances stimulate cell apoptosis by increasing oxidative stress.This apoptosis then triggers the immunological response,which combines photodynamic therapy and T-cell-mediated immunotherapy to treat cancer.Furthermore,MNPT can be utilized as a contrast agent in magnetic resonance and fluorescence dual-modality imaging to give real-time tracking and feedback on treatment.
Chen Bai;Jiajing Liu;Luyao Bai;Dapeng Yao;Xiaofeng Li;Haoran Zhang;Dong Guo
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou,Jiangsu,221004,ChinaDepartment of Radiology,Xuzhou Cancer Hospital,Xuzhou,Jiangsu,221004,China
NanozymePhotodynamic therapyTumor microenvironmentImmunotherapyDual-mode tomography
《药物分析学报（英文）》 2024 (009)
1320-1329 / 10
This work was supported by the National Natural Science Foundation of China(Gtant No.:32201169)and the Natural Science Foundation of Jiangsu Province(Grant No.:BK20220662).We thank Dr.Fuxing Dong from the Public Experimental Research Center of Xuzhou Medical University for the help with the confocal micro-scope(Leica,STELLARIS 5)experiment.
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