β-elemene promotes miR-127-3p maturation,induces NSCLCs autophagy,and enhances macrophage M1 polarization through exosomal communicationOA
β-elemene promotes miR-127-3p maturation,induces NSCLCs autophagy,and enhances macrophage M1 polarization through exosomal communication
β-elemene has been observed to exert inhibitory effects on a multitude of tumors,primarily through multiple pathways such as the inhibition of cancer cell proliferation and the induction of apoptosis.The present study is designed to elucidate the role and underlying mechanisms of β-elemene in the thera-peutic intervention of non-small cell lung cancer(NSCLC).Both in vitro and in vivo experimental models corroborate the inhibitory potency of β-elemene on NSCLCs.Our findings indicate that β-elemene fa-cilitates the maturation of miR-127-3p by inhibiting CBX8.Functioning as an upstream regulator of MAPK4,miR-127-3p deactivates the Akt/mTOR/p70S6K pathway by targeting MAPK4,thereby inducing autophagy in NSCLCs.Additionally,β-elemene augments the packaging of miR-127-3p into exosomes via SYNCRIP.Exosomal miR-127-3p further stimulates M1 polarization of macrophages by suppressing ZC3H4.Taken together,the detailed understanding of the mechanisms through which β-elemene in-duces autophagy in NSCLCs and facilitates M1 polarization of macrophages provides compelling scientific evidence supporting its potential utility in NSCLC treatment.
Xiahui Wu;Jie Wu;Tingting Dai;Qiangcheng Wang;Shengjie Cai;Xuehan Wei;Jing Chen;Ziyu Jiang
Department of Oncology,Lianyungang Integrated Traditional Chinese and Western Medicine Clinical College,Nanjing University of Chinese Medicine,Nanjing,222002,China||Department of Oncology,The First People's Hospital of Lianyungang,Lianyungang,Jiangsu,222002,ChinaDepartment of Digestive System,Pukou Hospital of Traditional Chinese Medicine,Nanjing,210000,ChinaDepartment of Oncology,Jinling Hospital,School of Medicine,Nanjing University,Nanjing,210000,ChinaDepartment of Oncology,the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research,Nanjing,210000,ChinaThe Third Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing,210028,ChinaDepartment of Biochemistry and Molecular Biology,School of Medicine,Nanjing University of Chinese Medicine,Nanjing,210023,China
β-elemenemiR-127-3pNSCLCAkt/mTOR/p70S6KMAPK4
《药物分析学报（英文）》 2024 (009)
1347-1360 / 14
This work was supported by the National Natural Science Foundation of China(Grant No.:81973525),and Traditional Chi-nese Medicine Development Project of Jiangsu Province(Grant No.:ZT202112).
评论