miR-135b:An emerging player in cardio-cerebrovascular diseasesOA
miR-135b:An emerging player in cardio-cerebrovascular diseases
miR-135 is a highly conserved miRNA in mammals and includes miR-135a and miR-135b.Recent studies have shown that miR-135b is a key regulatory factor in cardio-cerebrovascular diseases.It is involved in regulating the pathological process of myocardial infarction,myocardial ischemia/reperfusion injury,cardiac hypertrophy,atrial fibrillation,diabetic cardiomyopathy,atherosclerosis,pulmonary hyperten-sion,cerebral ischemia/reperfusion injury,Parkinson's disease,and Alzheimer's disease.Obviously,miR-135b is an emerging player in cardio-cerebrovascular diseases and is expected to be an important target for the treatment of cardio-cerebrovascular diseases.However,the crucial role of miR-135b in cardio-cerebrovascular diseases and its underlying mechanism of action has not been reviewed.Therefore,in this review,we aimed to comprehensively summarize the role of miR-135b and the signaling pathway mediated by miR-135b in cardio-cerebrovascular diseases.Drugs targeting miR-135b for the treatment of diseases and related patents,highlighting the importance of this target and its utility as a therapeutic target for cardio-cerebrovascular diseases,have been discussed.
Yingchun Shao;Jiazhen Xu;Wujun Chen;Minglu Hao;Xinlin Liu;Renshuai Zhang;Yanhong Wang;Yinying Dong
The Affiliated Hospital of Qingdao University,Qingdao University,Qingdao Cancer Institute,Qingdao,266071,ChinaThe Affiliated Hospital of Qingdao University,Qingdao University,Qingdao Cancer Institute,Qingdao,266071,China||Department of Radiation Oncology,The Affiliated Hospital of Qingdao University,Qingdao,266071,China
miR-135bMyocardial injuryBrain injuryCardiovascular diseasesCerebrovascular diseases
《药物分析学报（英文）》 2024 (010)
1407-1417 / 11
This work was supported by the Natural Science Foundation of Shandong Province,China(Grant No.:ZR2023QH007),the Natural Science Foundation of Qingdao Municipality,China(Grant No.:23-2-1-135-zyyd-jch),the Shandong Postdoctoral Science Foundation,China(Grant No.:SDBX2023049),and the China Postdoctoral Sci-ence Foundation(Grant No.:2023M731852).Graphical abstract and Fig.3 created with BioRender.com.Figs.4-7 were drawn by Fig-draw(www.figdraw.com).
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