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首页|期刊导航|药物分析学报(英文)|"Small is beautiful"-Examining reliable determination of low-abundant therapeutic antibody glycovariants

"Small is beautiful"-Examining reliable determination of low-abundant therapeutic antibody glycovariants

Katharina Böttinger Christof Regl Veronika Schäpertöns Erdmann Rapp Therese Wohlschlager Christian G.Huber

药物分析学报(英文)2024,Vol.14Issue(10):1435-1449,15.
药物分析学报(英文)2024,Vol.14Issue(10):1435-1449,15.DOI:10.1016/j.jpha.2024.100982

"Small is beautiful"-Examining reliable determination of low-abundant therapeutic antibody glycovariants

"Small is beautiful"-Examining reliable determination of low-abundant therapeutic antibody glycovariants

Katharina Böttinger 1Christof Regl 2Veronika Schäpertöns 1Erdmann Rapp 3Therese Wohlschlager 1Christian G.Huber2

作者信息

  • 1. Department of Biosciences and Medical Biology,Bioanalytical Research Labs,University of Salzburg,Salzburg,5020,Austria
  • 2. Department of Biosciences and Medical Biology,Bioanalytical Research Labs,University of Salzburg,Salzburg,5020,Austria||Center for Tumorbiology and Immunology(CTBI),University of Salzburg,Salzburg 5020,Austria
  • 3. glyXera GmbH,Magdeburg,Sachsen-Anhalt,39014,Germany||Max Planck Institute for Dynamics of Complex Technical Systems,Magdeburg,39106,Germany
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摘要

关键词

Glycosylation/Mass spectrometry/Monoclonal antibodies/Abundance profiling/Minor glycovariants/Multi-level analysis/Data integration

Key words

Glycosylation/Mass spectrometry/Monoclonal antibodies/Abundance profiling/Minor glycovariants/Multi-level analysis/Data integration

引用本文复制引用

Katharina Böttinger,Christof Regl,Veronika Schäpertöns,Erdmann Rapp,Therese Wohlschlager,Christian G.Huber.."Small is beautiful"-Examining reliable determination of low-abundant therapeutic antibody glycovariants[J].药物分析学报(英文),2024,14(10):1435-1449,15.

基金项目

Acknowledgments go to Simon Obermaier for initial data treatment as part of his Bachelor thesis.The authors would furthermore like to acknowledge Wolfgang Esser-Skala for providing fragquaxi,MoFi,and CAFOG to the scientific community.This research was funded in whole or in part by the Austrian Sci-ence Fund(FWF)(FG 1201 N,"DigiTherapeutX"],.Figures were created in Inkscape(v1.3.1).Fig.S2 provides an explanation of the used symbol nomenclature and monosaccharide abbreviations. (FWF)

药物分析学报(英文)

2095-1779

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