中国实用儿科杂志2024，Vol.39Issue(11)：825-830,6.DOI:10.19538/j.ek2024110605
儿童纯合子家族性高胆固醇血症的治疗进展
Progress in the treatment of pediatric homozygous familial hypercholesterolemia
张军 1李燕虹1
作者信息
- 1. 中山大学附属第一医院儿科,广东 广州 510080
- 折叠
摘要
Abstract
Homozygous familial hypercholesterolemia(HoFH)is a rare,life-threatening disease.The main manifestation of the disease is a substantial elevation in low-density lipoprotein cholesterol levels,which can cause atherosclerotic vascular lesions including coronary arteries,beginning in the first ten years of life.HoFH is still a rare disease in pediatric clinical practice,and the diagnosis is usually postponed and the treatment is insufficient.A mutation in the low-density lipoprotein receptor(LDLR)gene is the most common cause of the illness.The disease requires early,intensive and individualized medication and multimodal treatment to improve the prognosis.This article focuses on the treatment progress of HoFH.关键词
儿童/纯合子家族性高胆固醇血症/高脂血症Key words
pediatrics/homozygous familial hypercholeste-rolemia/hyperlipidemia分类
医药卫生引用本文复制引用
张军,李燕虹..儿童纯合子家族性高胆固醇血症的治疗进展[J].中国实用儿科杂志,2024,39(11):825-830,6.
