中国实用内科杂志2024，Vol.44Issue(11)：901-905,5.DOI:10.19538/j.nk2024110105
垂体相关肉芽肿性多血管炎
Pituitary-related granulomatosis with polyangiitis
摘要
Abstract
Granulomatosis with polyangiitis(GPA)is a systemic disease closely related to anti-neutrophil cytoplasmic antibody(ANCA)and is characterized by immune necrotizing small vessel vasculitis.GPA can involve any organ system,with the most common target organs being the upper respiratory tract,lungs,and kidneys.GPA rarely involves the pituitary gland,accounting for approximately 1％of all GPA cases,and is often characterized by pituitary hormone dysfunction and/or imaging abnormalities in the saddle region.Pituitary involvement is often accompanied by symptoms of other organ involvement or might be the only clinical manifestation.Diagnosis requires a combination of systemic symptoms,saddle zone imaging,and serum ANCA measurement.Glucocorticoid hormones combined with cyclophosphamide or rituximab are routinely used to induce remission,with rituximab preferred in refractory or relapsed cases.Although other systemic disorders of GPA respond favorably to treatment,pituitary function,especially adenopituitary function,is often not restored,and some patients require lifelong hormone replacement therapy;early screening and treatment can help avoid irreversible pituitary damage and improve prognosis.关键词
肉芽肿性多血管炎/垂体炎/中枢性尿崩症Key words
granulomatosis with polyangiitis/hypophysitis/central diabetes insipidus分类
医药卫生引用本文复制引用
王柳,胡雨晨,张雨薇..垂体相关肉芽肿性多血管炎[J].中国实用内科杂志,2024,44(11):901-905,5.基金项目
四川省科技厅区域创新合作项目(24QYCX0424) （24QYCX0424）
四川省卫生厅干部保健课题(川干研-2023-107) （川干研-2023-107）
湖北陈孝平科技发展基金会(CXPJJH122012-024) （CXPJJH122012-024）
