中国实用内科杂志2024，Vol.44Issue(11)：906-910,5.DOI:10.19538/j.nk2024110106
自身免疫性垂体炎的再认识
Re-cognization of autoimmune hypophysitis
摘要
Abstract
Autoimmune hypophysitis is a rare organ-specific autoimmune disorder affecting the hypothalamus and pituitary gland,characterized by the infiltration of immune cells that impairs pituitary function to varying degreesand leads to pituitary enlargement in some patients,which may press adjacent tissues and organs,resulting in severe clinical manifestations and potentially life-threatening conditions.With a deeper understanding of autoimmune hypophysitis,more etiologies are being revealed,which in turn guides clinical decisions diagnosis and treatment.Although lymphocytic hypophysitis remains a relatively common type,the widespread use of immune checkpoint inhibitors in the treatment of malignant tumors has led to a growing recognition of hypophysitis as an immune-related adverse event.Paraneoplastic syndrome-associated hypophysitis is a type of autoimmune hypophysitis that is prone to misdiagnosis and underdiagnosis.Therefore,timely diagnosis and treatment is of great significance in improving patient prognosis in clinical practice.This paper aims to summarize the clinical features and,treatment and diagnosis principles of hypophysitis as an immune-related adverse event of immune checkpoint inhibitors and paraneoplastic syndrome related hypophysitis,in order to promote the recognition of such rare types of hypophysitis.关键词
自身免疫性垂体炎/淋巴细胞垂体炎/免疫检查点抑制剂/副肿瘤综合征Key words
autoimmune hypophysitis/lymphocytic hypophysitis/immune checkpoint inhibitors/paraneoplastic syndrome分类
医药卫生引用本文复制引用
徐甜,翟笑,朱惠娟..自身免疫性垂体炎的再认识[J].中国实用内科杂志,2024,44(11):906-910,5.基金项目
中国医学科学院医学与健康科技创新工程项目(2022-I2M-C&T-B-007) （2022-I2M-C&T-B-007）
