摘要
Abstract
Objective:To investigate the effects of Dabigatran Etexilate combined with Ticagrelor on coagulation function and myocardial indicators in elderly patients with atrial fibrillation and unstable angina pectoris.Method:A total of 97 elderly patients with atrial fibrillation and unstable angina pectoris at Zhongshan Hospital Affiliated to Xiamen University from January 2020 to June 2023 were selected as the study subjects.They were divided into study group(n=49)and control group(n=48)by random number table method.The control group was treated with Warfarin combined with Ticagrelor,while the study group was treated with Dabigatran Etexilate combined with Ticagrelor.Both groups were treated for 12 months.The coagulation function[thrombin time(TT),prothrombin time(PT),plasma activated partial thromboplastin time(APTT),international normalized ratio(INR)],myocardial indicators[plasma troponin I(cTnI),N-terminal pro brain natriuretic peptide(NT-proBNP),serum lipoprotein(a)]of the two groups before and after treatment were compared.The incidence of adverse reactions in the two groups was analyzed.Result:The TT,PT,APTT and INR of the study group were lower than those of the control group after treatment,the differences were statistically significant(P<0.05).The cTnI,NT-proBNP and lipoprotein(a)levels in the study group were lower than those in the control group after treatment,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with the combination of Warfarin and Ticagrelor,the combination of Dabigatran Etexilate and Ticagrelor is more beneficial for improving coagulation function in elderly patients with atrial fibrillation and unstable angina,helping to prevent myocardial injury,and has better safety.关键词
心房颤动/不稳定型心绞痛/华法林/达比加群酯/替格瑞洛/凝血功能/心肌损伤Key words
Atrial fibrillation/Unstable angina pectoris/Warfarin/Dabigatran Etexilate/Ticagrelor/Coagulation function/Myocardial injury
