摘要
Abstract
Objective:To explore the effect of different doses of Fosinopril in children with nephrotic syndrome or immunoglobulin A(IgA)nephropathy.Method:A total of 80 children with nephrotic syndrome or IgA nephropathy admitted to Ganzhou Maternal and Child Health Hospital from October 2018 to October 2023 were selected as the study objects,and they were divided into group A(conventional western medicine treatment,n=24),group B[on the basis of group A+Fosinopril 0.1 mg/(kg·d)treatment,n=28]and group C[on the basis of A+Fosinopril 0.3 mg/(kg·d)treatment,n=28]according to different treatment methods.Blood pressure,blood routine[white blood cells(WBC),hemoglobin(Hb)],liver function[alanine aminotransferase(ALT)],24 h urinary protein quantification,urine protein negative conversion rate,serum creatinine(Scr),serum potassium,creatinine clearance(Ccr)and adverse events were compared among the three groups.Result:After 6 months of treatment,systolic blood pressure,diastolic blood pressure and mean arterial pressure in group A were not significantly different from those before treatment(P>0.05).After 6 months of treatment,the systolic blood pressure,diastolic blood pressure and average arterial pressure of group B and group C were lower than those before treatment and those of group A,the differences were statistically significant(P<0.05).There were no significant differences in WBC,Hb and ALT in group A,group B and group C before treatment and 6 months after treatment(P>0.05).After 6 months of treatment,the urine protein conversion rate of group C was higher than that of group A and group B,and the urine protein conversion rate of group B was higher than that of group A,the differences were statistically significant(P<0.05).After 6 months of treatment,there were significant differences in Scr and blood potassium among the three groups(P<0.05);Scr in group B and group C was higher than that in group A,and blood potassium in group C was higher than that in group A,the differences were statistically significant(P<0.05).There was no significant difference in Ccr between the three groups before treatment and after 6 months of treatment(P>0.05).There were no serious adverse events in the three groups,and only 2 cases of mild dizziness in group C were cured after intervention.Conclusion:In addition to the conventional medication,Fosinopril has a better effect in the treatment of children with nephrotic syndrome or IgA nephropathy,and compared with 0.1 mg/(kg·d)of Fosinopril,0.3 mg/(kg·d)of Fosinopril has a more significant improvement in the urine protein negative rate of patients.关键词
不同剂量/福辛普利/肾病综合征/IgA肾病/患儿/血压/尿蛋白Key words
Different doses/Fosinopril/Nephrotic syndrome/IgA nephropathy/Children/Blood pressure/Urinary protein
