摘要
Abstract
Objective:To investigate the influencing factors of acute myocardial infarction(AMI)in patients with unstable angina pectoris(UAP)and the predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP)on the occurrence risk of AMI.Method:A total of 120 patients with UAP admitted to Shangrao People's Hospital from February 2021 to February 2023 were selected as the study objects.The level of NT-proBNP was detected in all patients,and the level of NT-proBNP in patients with UAP with different severity was compared.Followed up for 1 year,the occurrence of AMI in patients with UAP was recorded,and they were divided into two groups according to whether AMI occurred:occurrence group(n=23)and non-occurrence group(n=97).Multivariate logistic regression analysis was performed for UAP patients with AMI.The receiver operator characteristic(ROC)curve was drawn,and the area under the curve(AUC)was used to evaluate the predictive efficacy of NT-proBNP on the occurrence risk of AMI in patients with UAP.Result:The difference of NT-proBNP in patients with UAP with different severity was statistically significant(P<0.05).NT-proBNP in severe group was higher than that in mild group and moderate group,and NT-proBNP in moderate group was higher than that in mild group,the differences were statistically significant(P<0.05).Among 120 patients with UAP,23 cases(19.17%)occurred AMI.The proportion of severe UAP and NT-proBNP in the occurrence group were higher than those in the non-occurrence group,the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that severe UAP[OR=3.550,95%CI(1.213,10.387)]and NT-proBNP[OR=3.991,95%CI(1.364,11.676)]were all independent risk factors of the occurrence of AMI in patients with UAP(P<0.05).ROC curve analysis results showed that the sensitivity of NT-proBNP in predicting AMI occurrence in patients with UAP was 69.57%,and the specificity was 79.81%,the AUC was 0.721[95%CI(0.635,0.797)].Conclusion:The severity of UAP and NT-proBNP are all influencing factors of the occurrence of AMI in patients with UAP,and NT-proBNP has certain predictive value for the occurrence of AMI in patients with UAP.关键词
不稳定型心绞痛/N末端脑钠肽前体/急性心肌梗死Key words
Unstable angina pectoris/N-terminal pro-brain natriuretic peptide/Acute myocardial infarction
