中国医院用药评价与分析2024，Vol.24Issue(11)：1313-1317,5.DOI:10.14009/j.issn.1672-2124.2024.11.005
杏苏饮联合揿针对变应性鼻炎合并支气管哮喘患儿的临床疗效及对免疫平衡、血清IL-37和IL-27水平的影响
Clinical Efficacy of Xingsu Decoction Combined with Thumbtack Needle in the Treatment of Children with Allergic Rhinitis Complicated with Bronchial Asthma and Its Effects on Immune Balance,Serum IL-37 and IL-27
摘要
Abstract
OBJECTIVE:To observe the clinical efficacy of Xingsu decoction combined with thumbtack needle in the treatment of children with allergic rhinitis complicated with bronchial asthma and its effects on immune balance,serum interleukin(IL)37 and IL-27.METHODS:A total of 88 children with allergic rhinitis complicated with bronchial asthma admitted into the hospital from Aug.2021 to Aug.2023 were divided into Western medicine group and Xingsu decoction combined with thumbtack needle group according to the random number table method.Forty-four patients in the Western medicine group received basic Western medicine treatment,and 44 patients in the Xingsu decoction combined with thumbtack needle group received Xingsu decoction combined with thumbtack needle on the basis of the Western medicine group.The clinical efficacy of two groups was compared,the traditional Chinese medicine syndrome scores of two groups were observed before and after treatment,the allergic rhinitis symptom score(TNSS+TNNSS)and asthma control test(ACT)form were evaluated,and the nasal resistance,forced expiratory volume at one second(FEV1)and nasal secretion eosinophils(EOS)levels were detected.Th17/Treg values,IL-37 and IL-27 levels were detected.RESULTS:The total effective rate of Xingsu decoction combined with thumbtack needle was 97.73%(43/44),higher than 81.82%(36/44)of Western medicine group,the difference was statistically significant(P<0.05).After treatment,the scores of wheezing or light wheezing in the morning and evening,sneezing in case of cold,phlegm cough in the morning,poor appetite,spontaneous sweating,and sticky stool in Xingsu decoction combined with thumbtack needle group were lower than those in Western medicine group,the score of ACT was higher than that of Western medicine group,and the score of TNSS+TNNSS was lower than that of Western medicine group,with statistically significant differences(P<0.05).After treatment,the nasal resistance and EOS in the Xingsu decoction combined with thumbtack needle group were lower than those in the Western medicine group,FEV1 was higher than that of Western medicine group,IL-27 and IL-37 levels were higher than those of Western medicine group,and Th17/Treg was lower than that of Western medicine group,with statistically significant differences(P<0.05).CONCLUSIONS:Xingsu decoction combined with thumbtack needle in the treatment of children with allergic rhinitis complicated with bronchial asthma can regulate the immune balance,increase the IL-27 and IL-37 levels,inhibit the inflammation,reduce the nasal resistance and EOS level,alleviate the disease conditions,improve the lung function and clinical efficacy.关键词
杏苏饮/揿针/变应性鼻炎合并支气管哮喘/患儿/免疫平衡/临床疗效Key words
Xingsu decoction/Thumbtack needle/Allergic rhinitis complicated with bronchial asthma/Children/Immune balance/Clinical efficacy分类
医药卫生引用本文复制引用
王伊娜,张崧,胡志佳..杏苏饮联合揿针对变应性鼻炎合并支气管哮喘患儿的临床疗效及对免疫平衡、血清IL-37和IL-27水平的影响[J].中国医院用药评价与分析,2024,24(11):1313-1317,5.基金项目
国家中医药管理局全国优秀人才研修项目(No.2020ZYLCY006-058) （No.2020ZYLCY006-058）
秦皇岛市科学技术研究与开发计划项目(No.202301A169) （No.202301A169）
