中国医院用药评价与分析2024，Vol.24Issue(11)：1323-1328,6.DOI:10.14009/j.issn.1672-2124.2024.11.007
从"瘀毒"论治冠心病的古方用药规律及其作用机制探索
Medication Rules and Mechanism of Ancient Prescription in the Treatment of Coronary Heart Disease from the Theory of"Stasis Toxin"
摘要
Abstract
OBJECTIVE:According to research methods of data mining and network pharmacology,to probe into the medication rules and mechanism of ancient traditional Chinese medicine prescription in the treatment of coronary heart disease from the theory of"Stasis Toxin",and to explore its core traditional Chinese medicine group and mechanism of action.METHODS:The ancient prescriptions extracted from the literature database were data-mined by using the Cloud Platform of Ancient and Modern Medical Cases,and the core group of traditional Chinese medicines was extracted.The mechanism in the treatment of coronary heart disease was investigated by network pharmacology.RESULTS:Totally 208 ancient prescriptions were extracted.Among them,the top three ranked by frequency of traditional Chinese medicines were Angelicae sinensis radix,Chuanxiong rhizoma,and Panax ginseng C.A.Mey.The four Qi contained warmth,calmness,slight coldness,coldness,and slight warmth.The five flavors were mainly pungent,bitter,and sweet,with the liver meridian and the spleen meridian as the main meridian.The core group of traditional Chinese medicine was Panax ginseng C.A.Mey,Angelicae sinensis radix,and Chuanxiong rhizoma.There were 28 traditional Chinese medicine active components,685 traditional Chinese medicine active component targets,1 450 disease targets and 190 common targets in the core group of traditional Chinese medicine.There were 40 core targets,including interleukin 6,tumor necrosis factor,protein kinase B1 and PPARG.Angelicae sinensis radix-Panax ginseng C.A.Mey-Chuanxiong rhizoma plays a role in the treatment of coronary heart disease through multiple pathways.CONCLUSIONS:Ancient prescription in the treatment of coronary heart disease from the theory of"Stasis Toxin"plays a role in the treatment of coronary heart disease through multi-components,multi-targets and multi-pathways,and its mechanism has similarities with the"Theory of Stasis Toxin"and"Theory of Inflammation"in modern research,which provides reliable theoretical basis for future related research.关键词
冠心病/瘀毒/数据挖掘/网络药理学/作用机制Key words
Coronary heart disease/Stasis toxin/Data mining/Network pharmacology/Mechanism分类
医药卫生引用本文复制引用
刘萍,贡磊磊,高宏杰,张一颖..从"瘀毒"论治冠心病的古方用药规律及其作用机制探索[J].中国医院用药评价与分析,2024,24(11):1323-1328,6.基金项目
中国中医科学院基本科研业务费自主选题项目(第十六批)(No.ZZ160309) （第十六批）
