中国医院用药评价与分析2024，Vol.24Issue(11)：1333-1335,1339,4.DOI:10.14009/j.issn.1672-2124.2024.11.009
造血干细胞移植患者霉酚酸药-时曲线下面积有限采样模型的应用研究
Application of Limited Sampling Strategy Model for the Area Under the Concentration-Time Curve of Mycophenolic Acid in Hematopoietic Stem Cell Transplantation Recipients
摘要
Abstract
OBJECTIVE:To perform limited sampling strategy(LSS)model for the area under the concentration-time curve of mycophenolic acid(MPA-AUC)in hematopoietic stem cell transplantation recipients(HSCT),so as to provide reference for rational clinical evaluation of drug exposure for mycophenolic acid.METHODS:Patients who received allogeneic HSCT at the hospital from Apr.2022 to Mar.2024 were enrolled.Intensive sampling was performed on the 8th day of mycophenolate mofetil administration.MPA plasma concentrations at 8 sampling points from before administration to after administration of 12 h were collected and monitored.MPA-AUC was calculated by using trapezoidal method.The published LSS model was used to predict MPA-AUC outcomes in these patients,and the two sets of results were compared to evaluate the predictive ability of the LSS model.RESULTS:A total of 25 patients were included and 200 MPA plasma concentrations were collected.The average MPA-AUC0-12 h calculated by trapezoidal method was(16.33±4.10)mg·h/L(from 8.28 to 25.25 mg·h/L).The average MPA-AUC0-12 h calculated by LSS model was(16.15±4.17)mg·h/L(from 9.28 to 27.59 mg·h/L),and there was no significant difference between two methods(P>0.05).Multivariate analysis indicated that the correlation between plasma concentration and AUC was low at all time points except for the plasma concentration at 12 h after MMF administration.The absolute prediction deviation(APE)of the model wass(2.44±1.56)mg·h/L,with APE%<20%.CONCLUSIONS:The LSS model in this study has acceptable predictive performance,which can be used for the therapeutic drug monitoring of MPA in HSCT in the hospital,and is a good method to evaluate the drug exposure of MPA.关键词
霉酚酸/药-时曲线下面积/有限采样模型/造血干细胞移植Key words
Mycophenolic acid/AUC/Limited sampling model/Hematopoietic stem cell transplantation分类
医药卫生引用本文复制引用
林良沫,洪绵慧,符祥俊..造血干细胞移植患者霉酚酸药-时曲线下面积有限采样模型的应用研究[J].中国医院用药评价与分析,2024,24(11):1333-1335,1339,4.基金项目
海南省自然科学基金资助项目(No.822QN452) （No.822QN452）
