中国医院用药评价与分析2024，Vol.24Issue(11)：1348-1351,4.DOI:10.14009/j.issn.1672-2124.2024.11.013
伏诺拉生与枳术宽中胶囊联合应用对胃食管反流病患者预后的疗效及对HO-1、GSH表达水平的影响
Prognosis and Efficacy of Vonoprazan Combined with Zhizhu Kuanzhong Capsule in the Treatment of Patients with Gastroesophageal Reflux Disease and Its Effects on Expression Levels of HO-1 and GSH
摘要
Abstract
OBJECTIVE:To probe into the the prognosis and efficacy of vonoprazan combined with Zhizhu Kuanzhong capsule in the treatment of patients with gastroesophageal reflux disease(GERD)and its effects on expression levels of heme oxygenase-1(HO-1)and glutathione(GSH).METHODS:Totally 120 patients with GERD admitted into the hospital from May 1st,2022 to May 1st,2023 were extracted to be divided into two groups by digital lottery grouping method.The control group(n=60)and study group(n=60)respectively received vonoprazan and vonoprazan combined with Zhizhu Kuanzhong capsule.The efficacy,expression levels of HO-1 and GSH,gastroesophageal reflux disease questionnaire(GERDQ)score,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6]levels and incidence of adverse drug reactions of two groups were compared.RESULTS:The effective rate of the study group was 96.67%(58/60),higher than 81.67%(49/60)of the control group,the difference was statistically significant(P<0.05).There was no significant difference in serum indexes(HO-1,GSH),symptom score(GERDQ)and inflammatory factors(TNF-α,IL-1β,IL-6)between two groups before treatment(P>0.05).After treatment,HO-1 in the study group was lower than that in the control group,GSH was higher than that in the control group,GERDQ score was lower than that in the control group,the levels of TNF-α,IL-1β and IL-6 were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the study group and the control group was respectively 5.00%(3/60)and 6.67%(4/60),with no statistically significant difference(P>0.05).CONCLUSIONS:The clinical efficacy of vonoprazan combined with Zhizhu Kuanzhong capsule in the treatment of GERD is better,and the laboratory indicators and clinical symptoms of GERD can be significantly improved with higher safety.关键词
伏诺拉生/枳术宽中胶囊/胃食管反流病/血红素氧合酶-1/谷胱甘肽Key words
Vonoprazan/Zhizhu Kuanzhong capsule/Gastroesophageal reflux disease/Heme oxygenase-1/Glutathione分类
医药卫生引用本文复制引用
田燕,孙晶,杨长青..伏诺拉生与枳术宽中胶囊联合应用对胃食管反流病患者预后的疗效及对HO-1、GSH表达水平的影响[J].中国医院用药评价与分析,2024,24(11):1348-1351,4.基金项目
山西省应用基础研究计划项目(No.202202B121024) （No.202202B121024）
