中国医院用药评价与分析2024，Vol.24Issue(11)：1352-1354,1359,4.DOI:10.14009/j.issn.1672-2124.2024.11.014
基于电子诊疗数据的痰热清注射液联合用药疑似过敏反应风险的嵌套病例对照研究
Nested Case-Control Study on Risk of Suspected Allergic Reactions Induced by Drug Combination of Tanreqing Injection Based on Electronic Diagnosis and Treatment Data
摘要
Abstract
OBJECTIVE:To explore the correlation between Tanreqing injection and suspected allergic reactions in patients with common drug combination.METHODS:Case data of patients with Tanreqing injection recorded in Bethune International Peace Hospital of the Chinese People's Liberation Army and Affiliated Hospital of Hebei University of Traditional Chinese Medicine from Jan.2018 to Jun.2023 were collected for nested case-control study.The control group cases were screened by age,gender and department by using propensity value matching method.Suspected allergic reactions were evaluated by anti-allergic drugs,and sensitivity analysis was conducted by univariate analysis and multivariate Logistic regression analysis with expanded sample size.RESULTS:Totally 403 patients with Tanreqing injection were selected as the study group.Multivariate Logistic regression analysis showed that the combination of Tanreqing injection and five drugs increased the risk of allergic reactions,namely ceftriaxone(OR=3.476,95%CI=2.473-4.205),lidocaine(OR=1.462,95%CI=1.136-1.801),ambroxol(OR=1.225,95%CI=1.013-1.522),moxifloxacin(OR=1.904,95%CI=1.257-2.469)and vitamin C(OR=1.436,95%CI=1.107-1.834);while the combination of Tanreqing injection and ceftiamidine(OR=0.711,95%CI=0.562-1.112)reduced the risk of allergic reactions.The sensitivity analysis results were basically consistent.CONCLUSIONS:The suspected allergic reactions of Tanreqing injection may be related to drug combination of five drugs(ceftriaxone,lidocaine,ambroxol,moxifloxacin and vitamin C),care should be taken in the clinical drug combination.关键词
痰热清注射液/过敏反应/联合用药/敏感性分析/不良反应/Logistic回归Key words
Tanreqing injection/Allergic reactions/Drug combination/Sensitivity analysis/Adverse drug reactions/Logistic regression分类
医药卫生引用本文复制引用
冯荣伟,张金虎,殷玮,刘婷婷,王文习..基于电子诊疗数据的痰热清注射液联合用药疑似过敏反应风险的嵌套病例对照研究[J].中国医院用药评价与分析,2024,24(11):1352-1354,1359,4.基金项目
河北省中医药管理局科研计划项目(No.2020264) （No.2020264）
