中国医院用药评价与分析2024，Vol.24Issue(11)：1397-1401,1408,6.DOI:10.14009/j.issn.1672-2124.2024.11.023
青礞石治疗癫痫的作用机制及临床应用研究进展
Progress on Mechanism of Action and Clinical Application of Chloriti Lapis in the Treatment of Epilepsy
摘要
Abstract
Chloriti Lapis,as a mineral medicine,is sweet and salty in taste,neutral in nature,and enters the lung,heart,and liver meridians.It has the functions of resolving phlegm,descending Qi,soothing the liver,and calming the mind.It is used for conditions such as stubborn phlegm accumulation,cough with dyspnea,epilepsy with mania,irritability,chest tightness,and convulsions due to fright.Studies have shown that Chloriti Lapis can reduce the hippocampal neuron apoptosis,inhibit the excessive expression of inflammatory factors,inhibit the excitatory neurotransmitters to reduce abnormal brain discharges,and interfere with the reconstruction of intestinal microecology by reducing the abundance of Proteobacteria,thereby inhibiting epileptic discharges through the"cerebro-intestinal axis".Clinical studies have confirmed the significant anti-epileptic efficacy of Chloriti Lapis.By reviewing relevant literature,this article explores the mechanism of action and clinical application of Chloriti Lapis in the treatment of epilepsy,aiming to provide reference for the development of new clinical traditional Chinese medicines.关键词
青礞石/癫痫/作用机制/临床应用/研究进展Key words
Chlorite Lapis/Epilepsy/Mechanism of action/Clinical application/Research progress分类
医药卫生引用本文复制引用
吴广,铁梦意,杨俊红,朱健,潘知玉,刘金民,荆志伟..青礞石治疗癫痫的作用机制及临床应用研究进展[J].中国医院用药评价与分析,2024,24(11):1397-1401,1408,6.基金项目
国家自然科学基金资助项目(No.82074584) （No.82074584）
中国中医科学院科技创新工程项目(No.CI2021A04702) （No.CI2021A04702）
