|国家科技期刊平台
| 注册
首页|期刊导航|Neural Regeneration Research|Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng

Neural Regeneration Research2025，Vol.20Issue(11)：P.3287-3301,15.
✕
Neural Regeneration Research2025，Vol.20Issue(11)：P.3287-3301,15.DOI:10.4103/NRR.NRR-D-23-01256

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

Ziwei Fan 1Mengxian Jia 1Jian Zhou 1Zhoule Zhu 1Yumin Wu 1Xiaowu Lin 1Yiming Qian 2Jiashu Lian 1Xin Hua 3Jianhong Dong 2Zheyu Fang 3Yuqing Liu 2Sibing Chen 2Xiumin Xue 2Juanqing Yue 4Minyu Zhu 5Ying Wang 6Zhihui Huang 1Honglin Teng5

作者信息

  • 1. Department of Orthopedics(Spine Surgery),the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang Province,China School of Pharmacy,Hangzhou Normal University,Hangzhou,Zhejiang Province,China
  • 2. School of Pharmacy,Hangzhou Normal University,Hangzhou,Zhejiang Province,China
  • 3. School of Pharmacy,Hangzhou Normal University,Hangzhou,Zhejiang Province,China Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang Province,China
  • 4. Department of Pathology,Affiliated Hangzhou First People’s Hospital,School of Medicine,Westlake University,Hangzhou,Zhejiang Province,China
  • 5. Department of Orthopedics(Spine Surgery),the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang Province,China
  • 6. Department of Clinical Research Center,Affiliated Hangzhou First People’s Hospital,School of Medicine,Westlake University,Hangzhou,Zhejiang Province,China
  • 折叠

摘要

关键词

cGAS/STING/functional recovery/microglia/neuroinflammation/neuroprotection/nuclear factor-κB/polarization/spinal cord injury/tryptanthrin

分类

医药卫生

引用本文复制引用

Ziwei Fan,Mengxian Jia,Jian Zhou,Zhoule Zhu,Yumin Wu,Xiaowu Lin,Yiming Qian,Jiashu Lian,Xin Hua,Jianhong Dong,Zheyu Fang,Yuqing Liu,Sibing Chen,Xiumin Xue,Juanqing Yue,Minyu Zhu,Ying Wang,Zhihui Huang,Honglin Teng..Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury[J].Neural Regeneration Research,2025,20(11):P.3287-3301,15.

基金项目

supported by the National Natural Science Foundation of China,Nos.82071387(to HT),81971172(to YW) （to HT）

the Natural Science Foundation of Zhejiang Province,China,No.LY22H090012(to HT) （to HT）

the Basic Research Project of Wenzhou City,China,No.Y20220923(to MZ)。 （to MZ）

Neural Regeneration Research

1673-5374

访问量0
|
下载量0
段落导航相关论文