首页|期刊导航|Neural Regeneration Research|The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer''''s disease

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer''''s disease

Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha

Neural Regeneration Research2025，Vol.20Issue(11)：P.3330-3344,15.

Neural Regeneration Research2025，Vol.20Issue(11)：P.3330-3344,15.DOI:10.4103/NRR.NRR-D-23-01890

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer''''s disease

Xueyan Liu ¹Wei Wu ²Xuejuan Li ¹Chengyan Wang ³Ke Chai ²Fanru Yuan ¹Huijuan Zheng ¹Yuxing Yao ⁴Chenlu Li ⁵Zu-Cheng Ye ²Daijun Zha⁴

作者信息

1. Department of Medicinal Chemistry,School of Pharmacy,Fujian Medical University,Fuzhou,Fujian Province,China Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases,School of Basic Medical Sciences,Fujian Medical University,Fuzhou,Fujian Province,China
2. Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases,School of Basic Medical Sciences,Fujian Medical University,Fuzhou,Fujian Province,China
3. Institute of Laboratory Animal Center,Fujian Medical University,Fuzhou,Fujian Province,China
4. Department of Medicinal Chemistry,School of Pharmacy,Fujian Medical University,Fuzhou,Fujian Province,China
5. Department of Neurosurgery,Neurosurgery Research Institute,The First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,China Department of Hyperbaric Oxygen,National Regional Medical Center,Binhai Campus of the First Affiliated Hospital,Fujian Medical University,Fuzhou,Fujian Province,China
折叠

摘要

关键词

Alzheimer''s disease/amyloid-β/astrocyte/cognitive impairment/D30/dendritic spines/galectin-3/microglia/neuroinflammation/neuron

分类

医药卫生

引用本文复制引用

Xueyan Liu,Wei Wu,Xuejuan Li,Chengyan Wang,Ke Chai,Fanru Yuan,Huijuan Zheng,Yuxing Yao,Chenlu Li,Zu-Cheng Ye,Daijun Zha..The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer''''s disease[J].Neural Regeneration Research,2025,20(11):P.3330-3344,15.

基金项目

supported by the Research Foundation for Talented Scholars of Fujian Medical University,No.XRCZX2018014(to DZ) （to DZ）

Startup Fund for Scientific Research,Fujian Medical University,No.2019QH1017(to CW) （to CW）

the Natural Science Foundation of Fujian Province,China,Nos.2021J01693(to DZ),2021J02032(to ZCY)。（to DZ）

Neural Regeneration Research

ISSN：1673-5374

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