中医康复2025，Vol.2Issue(1)：60-65,6.DOI:10.19787/j.issn.2097-3128.2025.01.011
中药调节自噬相关信号通路改善激素性股骨头坏死的研究进展
Modulation of Autophagy-Related Signaling Pathway by Traditional Chinese Medicine to Ameliorate Steroid-Induced Avascular Necrosis of the Femoral Head:A Research Progress
摘要
Abstract
Steroid-induced avascular necrosis of the femoral head(SANFH)is a common and frequently-occurring disease in the clinical orthopedic system,its cause is the ischemia and hypoxia of the femoral head caused by the irrational use of hormones,which eventually develops into femoral head necrosis.At present,there is no specific drug for the treatment of SANFH,but with the progress of research,autophagy has been found to play an important role in the pathogenic process of the disease,and it has been clarified that part of the signaling pathway can have an effect on autophagy.At this stage,the research of Chinese medicine against SANFH has attracted much attention,but its mechanism of action is still unclear.In this ar-ticle,we reviewed the relevant domestic and international literature to provide an overview of the relationship between autophagy(osteoblasts,osteo-clasts,mitochondria,etc)and SANFH,and the modulation of autophagy-related signaling pathways by traditional Chinese medicines(Such as as-tragalus polysaccharide,puerarin,naringin,Chuanxiongzine,epimedium glycosides and other Chinese medicine monomers and compounds,as well as Guizhi Shaoyao Zhimu soup,Yougui drink,Bone Strengthening powder,Gubi Tongxiao decoction,Huoxue Tongluo Soup,and other Chinese medicine compound formulae),with the aim of expanding the therapeutic measures and clarifying the value of traditional Chinese medicines in the treatment of SANFH.关键词
激素性股骨头坏死/自噬/中药/单体/复方/信号通路/凋亡/成骨细胞/破骨细胞Key words
steroid-induced necrosis of the femoral head(SANFH)/autophagy/traditional Chinese medicine/monomers/compound prescription/signaling pathway/apoptosis/osteoblast/osteoclast分类
医药卫生引用本文复制引用
马平,齐鑫,陈欣,胡紫阳,刘建军..中药调节自噬相关信号通路改善激素性股骨头坏死的研究进展[J].中医康复,2025,2(1):60-65,6.基金项目
张晓刚全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
甘肃省自然科学基金项目(23JRRA1192) （23JRRA1192）
兰州市科技计划项目(2022-ZD-91) （2022-ZD-91）
兰州市人才创新创业项目(2020-RC-64) （2020-RC-64）
甘肃省教育厅高等学校创新基金项目(2022B-109) （2022B-109）
甘肃省青年科技基金(20JRTORA345) （20JRTORA345）
兰州市城关区科技计划项目(2020-2-2-7) （2020-2-2-7）
2021年卫生健康行业科研项目(GSWSKY2021-069) （GSWSKY2021-069）
甘肃省中医药科研课题项目(GZKP-2021-16) （GZKP-2021-16）
