吉林大学学报（医学版）2024，Vol.50Issue(6)：1677-1682,6.DOI:10.13481/j.1671-587X.20240621
卵巢透明细胞癌和卵巢型子宫内膜异位症患者的临床特征分析
Analysis on clinical characteristics of patients with ovarian clear cell carcinoma and ovarian endometriosis
摘要
Abstract
Objective:To discuss the clinical characteristics of the patients with ovarian clear cell carcinoma(OCCC)and ovarian endometriosis(OMA),and to clarify the features of OCCC onset.Methods:A retrospective analysis was conducted on the clinical data of 80 patients with post-operative pathological diagnosis of OCCC and 80 OMA patients diagnosed by post-operative pathology,who received surgical treatment from March 2011 to May 2021.The analysis included general characteristics,clinical manifestations,laboratory indices,and imaging examination indexes.The age,body mass index(BMI),clinical symptoms such as abdominal pain,vaginal bleeding,and other symptoms(bloating,menstrual disorders,constipation,and abnormal vaginal discharge),preoperative serum carbohydrate antigen 125(CA125)levels,and ultrasound characteristics of ovarian cysts,such as cyst size,presence of pelvic effusion,and complexity,were compared between the patients in two groups.Multivariate Logistic regression analysis was used to identify the risk factors for OCCC,and the receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)was calculated.Results:Compared with OMA group,the age of the patients in OCCC group was significantly increased(P<0.05),the serum CA125 level was significantly increased(P<0.05),the diameter of ovarian cyst was significantly increased(P<0.05),and the percentage of the patients with pelvic effusion,other symptoms,and complex cysts was significantly increased(P<0.05).The multivariate Logistic regression analysis results showed that age≥40 years(OR=56.856,95%CI:5.611-576.082,P=0.001),complex ovarian cysts(OR=4.427,95%CI:1.025-19.114,P=0.046),concomitant pelvic effusion(OR=8.760,95%CI:1.574-48.760,P=0.013),and size of ovarian cysts(OR=1.782,95%CI:1.329-2.390,P<0.01)were the risk factors for OCCC.When the cut-off value of the ovarian cyst size was 7.35 cm,the sum of sensitivity(83.75%)and specificity(80.00%)was the highest,and the AUC was 0.883,indicating certain predictive value for identifying OCCC.Conclusion:The patients aged≥40 years with cysts≥7.35 cm in diameter,especially those with complex cysts accompanied by pelvic effusion,have a higher risk of malignancy to OCCC,and active intervention is recommended.关键词
卵巢透明细胞癌/卵巢型子宫内膜异位症/临床特征/危险因素/复杂性囊肿Key words
Ovarian clear cell carcinoma/Ovarian endometriosis/Clinical characteristic/Risk factor/Complex cyst分类
医药卫生引用本文复制引用
袁素珍,靳焰,汪雯雯..卵巢透明细胞癌和卵巢型子宫内膜异位症患者的临床特征分析[J].吉林大学学报（医学版）,2024,50(6):1677-1682,6.基金项目
国家自然科学基金青年科学基金项目(81701420) （81701420）
