吉林大学学报（医学版）2024，Vol.50Issue(6)：1763-1772,10.DOI:10.13481/j.1671-587X.20240632
脂蛋白a与钙化性主动脉瓣狭窄发生发展的关系及高脂蛋白a血症相关治疗的研究进展
Research progress in relationship between lipoprotein(a)and occurrence and development of calcific aortic valve stenosis and related treatment of hyperlipoprotein Aemia
摘要
Abstract
Lipoprotein(a)[Lp(a)]is a highly polymorphic lipoprotein molecule composed of apolipoprotein A(apo A),apo B100,and cholesterol ester core;calcific aortic valve stenosis(CAVS)is a multifactorial valvular heart disease influenced by both environmental and genetic factors.Lp(a)is an independent risk factor for CAVS and can increase the onset risk of CAVS.Lp(a)plays an important role in the treatment of CAVS.Although surgery is currently the main clinical treatment for CAVS,with further exploration into its pathological mechanism,drug therapy targeting Lp(a)has emerged as a new method.This paper reviews studies about the structure and characteristics of Lp(a),its role in the occurrence and development of CAVS,treatment options related to hyperlipoprotein Aemia,and the studies preventing and treating CAVS by combating inflammation,and enhances the clinicians'understanding and awareness of hyperlipoprotein Aemia and provides new insights for the prevention and targeted drug therapy of CAVS.关键词
脂蛋白a/钙化性主动脉瓣狭窄/主动脉瓣钙化/高脂蛋白a血症Key words
Lipoprotein(a)/Calcific aortic valve stenosis/Aortic valve calcification/Hyperlipoprotein Aemia分类
医药卫生引用本文复制引用
张莉,张梦圆,夏彬凤,孔敏,王茹,黄慧慧,尹霞..脂蛋白a与钙化性主动脉瓣狭窄发生发展的关系及高脂蛋白a血症相关治疗的研究进展[J].吉林大学学报（医学版）,2024,50(6):1763-1772,10.基金项目
吉林省卫健委卫生健康科技能力提升项目(2022LC103) （2022LC103）
吉林省科技厅自然科学基金项目(20200201609JC) （20200201609JC）
