中国耳鼻咽喉头颈外科2024，Vol.31Issue(11)：686-691,6.DOI:10.16066/j.1672-7002.2024.11.002
179例喉鳞状细胞癌临床病理特征及预后因素的回顾性研究
A retrospective study on clinicopathological features and prognostic factors of 179 cases of laryngeal squamous cell carcinoma
摘要
Abstract
OBJECTIVE To analyze the clinicopathological features of laryngeal squamous carcinoma tumors and their correlation with prognosis in order to improve the understanding and diagnosis of laryngeal squamous cell carcinoma.METHODS The clinical and pathological data(including gender,age,stage,differentiation,immunohistochemistry,etc.)of 179 patients with laryngeal squamous cell carcinoma[171 males,8 females,aged 30-84(61.53±8.02)years]who were treated in Department of Otolaryngology Head and Neck Surgery,The First and Second Clinical Medical Schools of Ningxia Medical University from January 2015 to December 2022 were retrospectively studied,and the effects of various factors on prognosis were analyzed.RESULTS Among the 179 patients with laryngeal squamous cell carcinoma,the male-to-female ratio was 21.4:1,and the incidence was high in the age group of 60-79 years old(58.7%),and the youngest age of onset was 30 years old.The main clinical manifestations were hoarseness 138 cases(77.1%),sore throat 16 cases(8.9%)and pharyngeal foreign body sensation 13 cases(7.3%).Glottic type was more common in the primary site 135 cases(75.4%),and 31 cases were accompanied by cervical lymph node metastasis(17.3%).The degree of differentiation was more common in the moderately differentiated type 80 cases(44.7%).The positive rates of immunohistochemistry markers p16,EGFR(epidermal growth factor receptor),PD-1/PD-L1 and VEGF(vascular endothelial growth factor)were 20.3%,96.4%,36.4%and 77.3%,respectively.Univariate Kaplan-Meier survival analysis showed that the site of disease,lymph node metastasis,and tumor stage were significantly correlated with disease recurrence.Multivariate Cox regression analysis showed that the clinical stage of the tumor was an independent risk factor for the prognosis of the disease(HR=3.715,95%CI:1.519-9.088,P=0.04).CONCLUSION The stage of laryngeal squamous cell carcinoma,the site of the disease,and the metastasis of the lymph nodes are the main factors affecting the prognosis.The high positive expression rate of immunohistochemistry markers EGFR and VEGF is worth paying attention to Targeted therapy for patients with positive PD-1/PD-L1 testing is a promising research direction.关键词
喉肿瘤/癌,鳞状细胞/预后/临床特征/病理特征/回顾性分析Key words
Laryngeal Neoplasms/Carcinoma,Squamous Cell/Prognosis/clinical features/pathological feature/retrospective analysis引用本文复制引用
弥志鹏,李永春,文武林,申学良,杨凤霞,杨梅花,章峪侨,陈宝丽,马瑞霞..179例喉鳞状细胞癌临床病理特征及预后因素的回顾性研究[J].中国耳鼻咽喉头颈外科,2024,31(11):686-691,6.基金项目
银川市科技计划项目(2024SFZD003) （2024SFZD003）
宁夏回族自治区重点研发计划项目(2018YBZD0145、2022BEG03103) （2018YBZD0145、2022BEG03103）
